{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:17Z","timestamp":1772160737233,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Lip exposure to carcinogens lead to several disorders, such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC). Although several studies have described important pathways in lip carcinogenesis, the comprehension of association of target genes in this process and their association with tumor microenvironment still need to be better understood.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Tissue samples of 30\u2009AC and 17 LLSCC cases were included for histopathological analysis, immunohistochemical expression of CD4, CD8, and PD\u2010L1, and fluorescence in\u00a0situ hybridization for\n AURKA<\/jats:italic>\n ,\n AURKB<\/jats:italic>\n ,\n TP53<\/jats:italic>\n ,\n PTEN<\/jats:italic>\n ,\n CCND1<\/jats:italic>\n , and\n MYC<\/jats:italic>\n . Non\u2010parametrical tests were done and\n p<\/jats:italic>\n \u2009<\u20090.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n LLSCC patients presented higher amplifications of\n AURKA<\/jats:italic>\n and\n AURKB<\/jats:italic>\n , deletion of\n TP53<\/jats:italic>\n , and\n PTEN<\/jats:italic>\n and rearrangements of\n MYC<\/jats:italic>\n than AC.\n AURKA<\/jats:italic>\n ,\n AURKB<\/jats:italic>\n ,\n TP53<\/jats:italic>\n ,\n PTEN<\/jats:italic>\n , and\n CCND1<\/jats:italic>\n changes were correlated with PD\u2010L1 expression.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n AURKA<\/jats:italic>\n and\n AURKB<\/jats:italic>\n amplifications and other gene changes are pointed by their association of lip disorders.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.13595","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T02:30:25Z","timestamp":1732847425000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Insights Into Actinic Cheilitis and Lower Lip Squamous Cell Carcinoma:\n \n AURKA<\/i>\n <\/scp>\n and\n \n AURKB<\/i>\n <\/scp>\n Amplifications and Their Association With Tumor Microenvironment"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-6928","authenticated-orcid":false,"given":"Vin\u00edcius Gon\u00e7alves","family":"de Souza","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital \u2013 Pio XII Barretos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-5841","authenticated-orcid":false,"given":"Ismael 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