{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:25:47Z","timestamp":1782167147251,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100023173","name":"Canadian Foundation for Dental Hygiene Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study explored the expression patterns of epithelial\u2010mesenchymal transition markers E\u2010cadherin and beta\u2010catenin in mild and moderate oral epithelial dysplasia (OED) to determine whether their expression predicts malignant progression in oral tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Formalin\u2010fixed paraffin\u2010embedded tissue specimens with mild or moderate dysplasia were retrieved from 87 patients. Immunohistochemistry was performed to compare E\u2010cadherin and beta\u2010catenin expression in tissue sections that progressed to severe dysplasia, carcinoma in\u00a0situ, or squamous cell carcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) with those that did not progress (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200958). Expression patterns were observed in the basal, parabasal, lower spinous, and upper spinous epithelial layers. Expression was assessed in the cell membrane for E\u2010cadherin and beta\u2010catenin (low expression\u2009=\u2009absent\/weak staining, high\u2009=\u2009moderate\/strong) and in the cytoplasm and nucleus for beta\u2010catenin (low\u2009=\u2009absence, high\u2009=\u2009presence). Logistic regression was used to predict progression based on the expression pattern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in the progression and expression patterns of E\u2010cadherin and beta\u2010catenin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found that the expression of E\u2010cadherin and beta\u2010catenin was not a predictor of early malignant progression, highlighting the importance of longitudinal studies in studying progression.<\/jats:p>\n                  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University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Oral Cancer Prevention Program, Cancer Control Research BC Cancer Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigha D.","family":"Rock","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Dalhousie University  Halifax Nova Scotia Canada"},{"name":"Beatrice Hunter Cancer Research Institute  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam P.","family":"Rosin","sequence":"additional","affiliation":[{"name":"BC Oral Cancer Prevention Program, Cancer Control Research BC Cancer Research Institute  Vancouver British Columbia Canada"},{"name":"Biomedical Physiology and Kinesiology Simon Fraser University  Burnaby British Columbia 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