{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:36Z","timestamp":1792686456197,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the efficacy of royal jelly in managing experimentally created MRONJ model in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty rats were randomly allocated into control, bisphosphonate (BP), royal jelly (RJ), Treatment, and Preventive groups. A defect was created in the alveolar socket following tooth extraction in the mandible as a surgical procedure in all groups. Before surgery, RJ was administered orally to the RJ group. Zoledronic acid was administered intraperitoneally to induce osteonecrosis in BP, treatment, and preventive group rats. Treatment group rats received RJ orally post\u2010surgery, while preventive group rats received it pre\u2010surgery. Histological and radiographic evaluations were performed post\u2010study completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Micro\u2010CT examinations demonstrated significantly improved values in RJ\u2010received groups (RJ, treatment, and preventive) compared to BP and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Immunohistochemical analysis revealed higher mean IL\u20101\u03b2 and TNF\u2010\u03b1 levels in the BP group. The highest IL\u20101\u03b2 difference was between BP and preventive groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). TNF\u2010\u03b1 expression levels in all RJ\u2010received groups were comparatively close to those of the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RJ enhances soft and hard tissue healing in MRONJ rat models, suggesting its potential as a therapeutic or preventive agent in osteonecrosis management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13627","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:14:59Z","timestamp":1741925699000},"page":"232-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Royal Jelly as a Therapeutic Intervention in Medication\u2010Related Osteonecrosis of the Jaw (\n                    <scp>MRONJ<\/scp>\n                    ): An Animal Model Study"],"prefix":"10.1111","volume":"54","author":[{"given":"Cihan","family":"Topan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Erciyes University Faculty of Dentistry  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suheyb","family":"Bilge","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Erciyes University Faculty of Dentistry  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-6415","authenticated-orcid":false,"given":"Ahmet Emin","family":"Demirbas","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Erciyes University Faculty of Dentistry  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcrkan","family":"A\u011fy\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Erciyes University Faculty of Dentistry  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u00e7a","family":"Kara","sequence":"additional","affiliation":[{"name":"Genom and Stem Cell Centre Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"issue":"6","key":"e_1_2_11_4_1","first-page":"2662","article-title":"A Systematic Review","volume":"25","author":"Goker F.","year":"2021","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050680"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.05.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2016.06.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.06.081"},{"issue":"6","key":"e_1_2_11_10_1","first-page":"6516","article-title":"Effect of Royal Jelly on New Bone Formation in Rapid Maxillary Expansion in Rats","volume":"20","author":"\u00d6zan F.","year":"2015","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2017.1363843"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020382"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2009.00878.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj9080085"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02678-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108694"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001943"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.803037"},{"key":"e_1_2_11_20_1","first-page":"563","article-title":"Interleukin\u20101, Tumor Necrosis Factor and Their Specific Inhibitors","volume":"5","author":"Dayer J. 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