{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:42:15Z","timestamp":1785883335603,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1190775"],"award-info":[{"award-number":["1190775"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is a common cancer, with a high propensity for regional lymph node metastasis (LnM), resulting in 5\u2010year survival rates of only 40%\u201350%. The premetastatic niche (PMN), a modified lymph node microenvironment preparing for future metastasis, is poorly understood. This study analyzes the histomorphological features of nonmetastatic lymph nodes from OSCC patients, stratified by the presence or absence of regional cervical LnM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study examined 424 nonmetastatic lymph nodes, preserved in paraffin blocks, from 45 OSCC patients. Histological analysis was performed using hematoxylin and eosin staining to evaluate architectural features, specifically capsule and trabeculae thickness, subcapsular and medullary sinus ectasia, fibrosis, follicular organization, and hyperplasia. Logistic regression models were used to assess the relationships between these features and LnM, recurrence, and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis revealed that intense medullary ectasia was associated with an increased risk of lymph node metastasis (LnM) (OR\u2009=\u20091.63; 95% CI: 0.99\u20132.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.051), whereas follicular hyperplasia appeared protective (OR\u2009=\u20090.27; 95% CI: 0.15\u20130.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Nonvisible sinusoidal trabeculae suggested a higher risk of recurrence (OR\u2009=\u20092.18; 95% CI: 0.99\u20134.81;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). Disorganized lymphoid follicles (OR\u2009=\u20091.91; 95% CI: 0.97\u20133.77;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.059), focal subcapsular ectasia (OR\u2009=\u20094.4; 95% CI: 1.34\u201314.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and marked subcapsular ectasia (OR\u2009=\u20093.2; 95% CI: 1.06\u20139.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) correlated with decreased survival. Conversely, follicular hyperplasia (OR\u2009=\u20090.38; 95% CI: 0.19\u20130.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and medullary fibrosis (OR\u2009=\u20090.13; 95% CI: 0.02\u20130.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) were associated with improved survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results highlight the potential clinical significance of follicular hyperplasia in lymph nodes. Patients exhibiting this feature may have a more favorable prognosis, characterized by increased survival and decreased risk of lymph node metastasis, regardless of concurrent alterations in other lymph node architecture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.13628","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T21:20:01Z","timestamp":1743974401000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nonmetastatic Lymph Node Histological Architecture Is Associated With Metastasis, Recurrence, and Survival in Oral Squamous Cell Carcinoma"],"prefix":"10.1111","volume":"54","author":[{"given":"Katherine","family":"Sabando\u2010Criollo","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda Universidad de los Andes, Chile  Santiago Chile"},{"name":"Magister de Investigaci\u00f3n e Innovaci\u00f3n en Odontolog\u00eda Universidad de los Andes, Chile  Las Condes Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Shanut","family":"Fern\u00e1ndez\u2010Cuya","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica Universidad de los Andes, Chile  Las Condes Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Lozano\u2010Burgos","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de Valpara\u00edso  Valpara\u00edso Chile"},{"name":"Carlos Van Buren Hospital  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-8117","authenticated-orcid":false,"given":"Ren\u00e9","family":"Mart\u00ednez\u2010Flores","sequence":"additional","affiliation":[{"name":"Carlos Van Buren Hospital  Valpara\u00edso Chile"},{"name":"Facultad de Odontolog\u00eda Universidad Andr\u00e9s Bello  Vi\u00f1a del Mar Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-4948","authenticated-orcid":false,"given":"Wilfredo Alejandro","family":"Gonz\u00e1lez\u2010Arriagada","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Universidad de los Andes, Chile  Santiago Chile"},{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n Biom\u00e9dica Universidad de los Andes, Chile  Las Condes Chile"},{"name":"Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT) Universidad de los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601206010126"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i28.10387"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168641"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104661"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105210"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2021.62.7.640"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2010.06.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2017.29.129-133"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21389"},{"key":"e_1_2_10_12_1","first-page":"66","article-title":"The Frequency of Occult Cervical Metastasis in Oral Squamous Cell Carcinoma Patients \u2010 a Cross Sectional Study","volume":"72","author":"Haseeb A. 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