{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T22:40:01Z","timestamp":1747262401812,"version":"3.40.5"},"reference-count":6,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Rare cancers are a diverse group of malignancies with low incidence, posing significant challenges for research due to the scarcity of cases and the lack of well\u2010established in\u00a0vitro and in\u00a0vivo models. In this letter, we describe how 3D bioprinting can address these challenges by enabling the construction of more accurate tumor models that capture the essential characteristics and heterogeneity of rare cancers. The technology allows for the creation of multicellular microenvironments, the incorporation of diverse extracellular matrix substrates, and the deployment of additional components like growth factors, nanoparticles, and genetic modulators. This versatility facilitates the study of complex tumor behaviors, such as perineural invasion, and enables high\u2010throughput drug screening for personalized therapies. We emphasize the transformative potential of 3D bioprinting in advancing rare cancer research and overcoming the longstanding challenges associated with these malignancies, with a particular focus on salivary gland cancers.<\/jats:p>","DOI":"10.1111\/jop.13634","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T22:24:28Z","timestamp":1743027868000},"page":"263-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing Research on Rare Cancers Through <scp>3D<\/scp> Bioprinting"],"prefix":"10.1111","volume":"54","author":[{"given":"Juliana Amorim","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Epithelial Biology, School of Dentistry, Department of Periodontics and Oral Medicine University of Michigan  Ann Arbor USA"},{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-1550","authenticated-orcid":false,"given":"Eliete Neves Silva","family":"Guerra","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Bras\u00edlia  Brasilia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-3429","authenticated-orcid":false,"given":"Cristiane H.","family":"Squarize","sequence":"additional","affiliation":[{"name":"Laboratory of Epithelial Biology, School of Dentistry, Department of Periodontics and Oral Medicine University of Michigan  Ann Arbor USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-612X","authenticated-orcid":false,"given":"Rogerio M.","family":"Castilho","sequence":"additional","affiliation":[{"name":"Laboratory of Epithelial Biology, School of Dentistry, Department of Periodontics and Oral Medicine University of Michigan  Ann Arbor USA"},{"name":"Rogel Cancer Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"issue":"4","key":"e_1_2_1_6_2_1","first-page":"123","article-title":"The Burden of Rare Cancers in North America","volume":"50","author":"Hofer B. 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