{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:23:43Z","timestamp":1783736623373,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patient\u2010reported outcomes (PRO), which prioritize patient perspectives, are highly valuable for patient\u2010centered care in Head and Neck Oncology. The objective of this study was to explore the longitudinal validity of the Edmonton\u201033 (E\u201033), a PRO instrument for assessing head and neck functions in swallowing, chewing, dry mouth, and speech.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved 59 adult patients (18 female, 41 male) with squamous cell carcinoma (SCC) of the oral cavity. Participants provided consent and completed the E\u201033 and other PRO instruments before and after surgical and radiation treatment at months 3 (<jats:italic>n<\/jats:italic>\u2009=\u200918), 6 (<jats:italic>n<\/jats:italic>\u2009=\u200918), and 9 (<jats:italic>n<\/jats:italic>\u2009=\u200916). Data were collected (from June 2021 to August 2024) and analyzed for correlation between domains of the E\u201033 and their domain\u2010specific, previously validated counterparts before treatment (baseline) and after treatment (Months 3, 6, and 9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were statistically significant correlations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) between all E\u201033 domains and their domain\u2010specific counterparts at baseline and at post\u2010treatment month 6. At Months 3 and 9 post\u2010treatment, there were partial correlations between E\u201033 domains and some domain\u2010specific counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The E\u201033 demonstrates validity pre\u2010treatment and post\u2010treatment at subacute timepoint (Months 6) for capturing data on swallowing, chewing, dry mouth, and speech, similar to other previously validated instruments. This validity is limited at the more acute timepoint of 3 months post\u2010treatment and the later timepoint of 9\u2009months post\u2010treatment. Additional data are needed to further explore the long\u2010term validity at further longitudinal timepoints at 1 and 2\u2009years post\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13640","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T04:54:30Z","timestamp":1746248070000},"page":"455-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the Edmonton\u201033: A Patient\u2010Reported Outcome Instrument in Head and Neck Oncology at Baseline and Subacute Phases Post\u2010Treatment"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-4574","authenticated-orcid":false,"given":"K.","family":"Zhang","sequence":"first","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry Western University  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Khan","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Seikaly","sequence":"additional","affiliation":[{"name":"Otolaryngology\u2014Head and Neck Surgery University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry Western University  London Canada"},{"name":"London Health Sciences Centre  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fung","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry Western University  London Canada"},{"name":"London Health Sciences Centre  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. D.","family":"MacNeil","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry Western University  London Canada"},{"name":"London Health Sciences Centre  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-5875","authenticated-orcid":false,"given":"A.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry Western University  London Canada"},{"name":"London Health Sciences Centre  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Patient\u2010Centred Outcomes in Head and Neck Oncology [dissertation]","author":"Mendez A.","year":"2017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2019.4788"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23399"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.09.008"},{"key":"e_1_2_11_6_1","unstructured":"D.Hicks A.Totten A.Berg K.Rader S.Goodman andR.Newhouse \u201cThe PCORI Methodology Report \u201d2013 http:\/\/www.pcori.org\/assets\/2013\/11\/PCORI\u2010Methodology\u2010Report.pdf."},{"key":"e_1_2_11_7_1","unstructured":"pcori \u201cPatient Engagement of the Patient\u2010Centered Outcomes Research Institute. Equity and Inclusion Guiding Engagement Principles \u201dhttps:\/\/www.pcori.org\/about\/pcoris\u2010advisory\u2010panels\/advisory\u2010panel\u2010patient\u2010engagement\/equity\u2010and\u2010inclusion\u2010guiding\u2010engagement\u2010principles."},{"key":"e_1_2_11_8_1","first-page":"870","article-title":"The Development and Validation of a Dysphagia\u2010Specific Quality\u2010Of\u2010Life Questionnaire for Patients With Head and Neck Cancer: The M. D. Anderson Dysphagia Inventory","volume":"127","author":"Chen A. Y.","year":"2001","journal-title":"Archives of Otolaryngology\u2014Head & Neck Surgery"},{"issue":"1","key":"e_1_2_11_9_1","first-page":"2","article-title":"Methods of Functional Outcomes Assessment Following Treatment of Oral and Oropharyngeal Cancer: Review of the Literature","volume":"37","author":"Mlynarek A. 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M.","year":"1999","journal-title":"Community Dental Health"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20795"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.13640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:26:41Z","timestamp":1751880401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.13640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jop.13640"],"URL":"https:\/\/doi.org\/10.1111\/jop.13640","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]},"assertion":[{"value":"2024-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}