{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:02:55Z","timestamp":1783695775745,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6682"],"award-info":[{"award-number":["2024JJ6682"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral squamous cell carcinoma (OSCC) is the most important histologic type of oral tumor. Integrin\u2010 and integrin\u2010dependent processes are involved in almost every step of cancer progression. Integrin \u03b1v\u03b23 was initially considered an integrin associated with tumor angiogenesis. With the gradual deepening of research, it was found that \u03b1v\u03b23 also plays a role in tumor cells. This study aimed to explore the function of tumor cell integrin \u03b1v\u03b23 in the progression of OSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemical methods in OSCC tissues explored the expression of integrin \u03b1v\u03b23. CCK\u20108, EdU, Cell cycle assay, Scratch test, Transwell, Cell adhesion assay, Colony formation assay, Apoptosis assay, and in\u00a0vivo experiment were performed to investigate the effects of integrin \u03b1v\u03b23 on the biological behaviors of OSCC cells such as proliferation, adhesion, migration, and invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we found that integrin \u03b1v\u03b23 expression was upregulated in OSCC. The inhibition of integrin \u03b1v\u03b23 expression by cilengitide resulted in the inhibition of proliferation, adhesion, migration, and invasion of OSCC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Integrin \u03b1v\u03b23 regulates cell proliferation by affecting the cell cycle. Furthermore, inhibition of integrin \u03b1v\u03b23 expression significantly suppresses migration and invasion of OSCC cells in\u00a0vitro and in\u00a0vivo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.70004","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T12:00:20Z","timestamp":1752408020000},"page":"597-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Study on Regulating <scp>OSCC<\/scp> Cell Function by Blocking Integrin \u03b1v\u03b23 With Cilengitide"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-0051","authenticated-orcid":false,"given":"Liujun","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Centre of Stomatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Research Center of Oral and Maxillofacial Tumor Xiangya Hospital, Central South 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