{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:18Z","timestamp":1772160738924,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.640723\/2021\u201300"],"award-info":[{"award-number":["88887.640723\/2021\u201300"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The existence of intraoral basal cell carcinoma (IOBCC) remains controversial, despite reported cases in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic search of four electronic databases and grey literature was conducted. Strict inclusion criteria were established to define a true case of IOBCC, including Ber\u2010EP4 positivity to distinguish it from peripheral ameloblastoma and the absence of a history of skin lesions\u2014either nearby, which could indicate direct infiltration, or at distant sites, which could suggest metastasis rather than a true primary IOBCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9 cases met the inclusion criteria. IOBCC lesions were located on the palate, buccal mucosa and gingiva, with no cases involving the tongue or floor of the mouth\u2014common sites for squamous cell carcinoma. Histologically, islands of basaloid cells with peripheral palisading and stromal retraction were the predominant findings. All cases were Ber\u2010EP4 positive. Six patients remained disease\u2010free during follow\u2010up, one experienced multiple recurrences, and two had no follow\u2010up data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IOBCC is extremely rare, with few documented cases. While previous studies suggested the gingiva as a common site, this review found no clear predilection, and some previously reported cases may have been misdiagnosed as peripheral ameloblastoma. Ber\u2010EP4 positivity in IHC is valuable for distinguishing between these entities. Additionally, by excluding cases with potential infiltration from skin lesions, this review underscores the importance of a thorough dermatological evaluation to rule out cutaneous extension or metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70005","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T07:24:31Z","timestamp":1750836271000},"page":"498-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoral Basal Cell Carcinoma: Controversies and Insights From a Systematic Review"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-3634","authenticated-orcid":false,"given":"Antonia Taiane Lopes","family":"de Moraes","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-936X","authenticated-orcid":false,"given":"Lauren Frenzel","family":"Schuch","sequence":"additional","affiliation":[{"name":"Department of Diagnosis in Pathology and Oral Medicine, School of Dentistry Universidad de la Rep\u00fablica (UDELAR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian Petersen","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"},{"name":"Department of Oral Medicine University of S\u00e3o Paulo (USP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<555::AID-IJC9>3.0.CO;2-R"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.6.681"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201072732\u2010x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2009.01236.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/39918"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.11.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896908329596"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2008.01059.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0089-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.06.018"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"438","article-title":"Intra\u2010Oral Basal Cell Carcinomaan Immunohistochemical Interpretation Using Ber\u2010Ep4","volume":"28","author":"Bajpai M.","year":"2016","journal-title":"Journal of Ayub Medical College, Abbottabad"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372\u2010200106000\u201000007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02722.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01223.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002163"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10982"},{"key":"e_1_2_11_20_1","volume-title":"WHO Classification of Skin Tumours","author":"Elder D. 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