{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:59:38Z","timestamp":1790791178178,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201021\u20100409"],"award-info":[{"award-number":["W81XWH\u201021\u20100409"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006386","name":"Adenoid Cystic Carcinoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adenoid cystic carcinoma (ACC) is a common salivary gland carcinoma with high recurrence and distant metastasis rates. Currently, there is no standard systemic treatment available. TROP2 is a transmembrane glycoprotein involved in the oncogenesis of several tumors that can be therapeutically targeted by a TROP2\u2010antibody\u2013drug conjugate (ADC). We aimed to characterize TROP2 expression in ACC and assess TROP2 as a potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TROP2 immunohistochemistry was performed in a tissue microarray including 165 ACC of salivary gland. The tumors were grouped according to the histological pattern as non\u2010solid, solid\u2009+\u2009non\u2010solid, or solid. TROP2 protein expression in ACC cell lines was assessed and subjected to drug screening with TROP2\u2010ADC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TROP2 expression was high in 59%, moderate in 30%, weak in 8%, and negative in 3% of cases. TROP2 expression was significantly higher in non\u2010solid compared with solid or solid\u2009+\u2009non\u2010solid (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Notably, TROP2 expression was heterogenous among the dual cellular component, with TROP2 expression identified predominantly in the ductal and not in the myoepithelial cells. In\u00a0vitro drug screening demonstrated that TROP2\u2010ADC had selective anti\u2010tumor effect in TROP2 expressing ACC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TROP2 expression is prevalent in ACC, particularly in the ductal cell component of the non\u2010solid tumors. The pre\u2010clinical drug screening findings provide a biological rationale for exploring TROP2 as a therapeutic target in TROP2\u2010expressing ACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      : NCT05884320; NCI\u20102023\u201004260\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70008","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T03:14:37Z","timestamp":1751944477000},"page":"658-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>TROP2<\/scp>\n                    Expression in Salivary Gland Adenoid Cystic Carcinoma (\n                    <scp>ACC<\/scp>\n                    ) According to Histologic Subtype: Therapeutic Implications"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5373-0141","authenticated-orcid":false,"given":"Juliana Mota","family":"Siqueira","sequence":"first","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology The University of Texas M.D. Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Stomatology, Discipline of Oral and Maxillofacial Pathology School of Dentistry, University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-4702","authenticated-orcid":false,"given":"Yoshitsugu","family":"Mitani","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas M.D. Anderson Cancer Center  Houston Texas 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Sousa","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology The University of Texas M.D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsumi","family":"Mitani","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology The University of Texas M.D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-5590","authenticated-orcid":false,"given":"Giovanna Lopes","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Discipline of Oral and Maxillofacial Pathology School of Dentistry, University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-6785","authenticated-orcid":false,"given":"Fabio Daumas","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Discipline of Oral and Maxillofacial Pathology School of Dentistry, University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Luongo","family":"Matos","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (Icesp, HCFMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiaw\u2010Yih","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Systems Biology The University of Texas M.D. Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Spiotto","sequence":"additional","affiliation":[{"name":"Department of Radiation 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