{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:22:45Z","timestamp":1790731365546,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus\u2010related cancer inflicts significant morbidity and mortality in adults. Real\u2010life data on the effectiveness of a vaccine are scarce. The purpose of the study was to assess the association between human papillomavirus vaccination and oral and oropharyngeal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Queries used de\u2010identified data from patients attending the University of Florida Gainesville Health Center for malignant neoplasm of the oral cavity and pharynx for patients diagnosed between October 2015 and September 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From a hospital population of 1\u2009743\u2009953 patients, 4 131 (0.23%) patients (1228 females and 2903 males) had oropharyngeal cancer. Males were likelier to have oral or oro\/oropharyngeal cancer (Odds Ratio\u2009=\u20092.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). 56\u2009654 (37\u2009479 females and 19\u2009175 males) were vaccinated, mostly Human papillomavirus 9\u2010VALENT (53%). The vaccine was associated with a reduced odds ratio for oral\/oropharyngeal cancer (Odds ratio 0.008,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) that remained low after adjustments for smoking status and alcohol abuse. When stratified by oropharyngeal and oral only, oral pharyngeal had a lower odds ratio with vaccination (0.01, 95%CI 0.00\u20130.06) compared to the oral cavity (0.03, 95% CI 0.01\u20130.10). There were also differences in the odds ratio with other risk factors such as gender, race, smoking, and alcohol abuse.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Human papillomavirus vaccination is associated with a reduced odds ratio for oral and oropharyngeal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70016","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T04:03:45Z","timestamp":1755749025000},"page":"895-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>HPV<\/scp>\n                    \u2010Vaccine and Reduced Odds Ratio for Oral and Oropharyngeal Cancer in Both Genders"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-8149","authenticated-orcid":false,"given":"J.","family":"Katz","sequence":"first","affiliation":[{"name":"Division of Oral Medicine University of Florida College of Dentistry  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health and Health Professionals  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry and Behavioral Sciences  College of Dentistry, Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917338"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6733a2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00603-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2108502"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_10_8_1","unstructured":"https:\/\/www.cdc.gov\/cancer\/hpv\/statistics\/cases.htm."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1600985"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs491"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.04.007"},{"key":"e_1_2_10_12_1","volume-title":"Human Papillomavirus Vaccination Among Adults Aged 18\u221226, 2013\u22122018. NCHS Data Brief, no 354. Hyattsville, MD","author":"Boersma P.","year":"2020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6833a3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa621"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106592"},{"key":"e_1_2_10_16_1","first-page":"11","article-title":"Human Papillomavirus DNA in Oral Squamous Cell Carcinomas and Normal Oral Mucosa","volume":"47","author":"Kansky A. 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