{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:42:23Z","timestamp":1757626943341,"version":"3.44.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) with nasal polyps is an inflammatory condition of the nasal mucosa accompanied by significant tissue remodeling. It is characterized by a type 2 inflammatory response and epithelial barrier dysfunction. Platelet\u2010derived growth factor receptor alpha (<jats:italic>PDGFRA<\/jats:italic>) is a proto\u2010oncogene that encodes a receptor tyrosine kinase for which platelet\u2010derived growth factor\u2010A (<jats:italic>PDGFA<\/jats:italic>) is a specific ligand. Immunoexpression of <jats:italic>PDGFRA<\/jats:italic> and upregulation of <jats:italic>PDGFRA<\/jats:italic> and <jats:italic>PDGFA<\/jats:italic> mRNAs have been demonstrated in CRS with nasal polyps, suggesting they participate in the pathophysiology of such lesions. <jats:italic>PDGFRA<\/jats:italic> pathogenic variants have been reported in inflammatory fibroid polyps, as well as in gastrointestinal stromal tumors. Although the pathogenesis of CRS with nasal polyps has been extensively studied, it remains unclear whether nasal polyps harbor genetic mutations. Therefore, herein we investigated the presence of <jats:italic>PDGFRA<\/jats:italic> pathogenic variants in nasal polyps occurring in the context of CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen CRS with nasal polyp samples were Sanger sequenced, targeting <jats:italic>PDGFRA<\/jats:italic> exons 12 and 18.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All samples exhibited wild\u2010type sequences for the <jats:italic>PDGFRA<\/jats:italic> sequenced regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that, unlike inflammatory fibroid polyps occurring in the gastrointestinal tract, the pathogenesis of nasal polyps occurring in CRS does not involve <jats:italic>PDGFRA<\/jats:italic> mutations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.70027","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T10:23:34Z","timestamp":1754562214000},"page":"742-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of <i>PDGFRA<\/i> Gene Pathogenic Variants in Nasal Polyps Associated With Chronic Rhinosinusitis"],"prefix":"10.1111","volume":"54","author":[{"given":"Tamara","family":"da Silva Vieira","sequence":"first","affiliation":[{"name":"Department of Pathology Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Martins","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Pathology Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte 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