{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:33Z","timestamp":1790304393133,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/17711\u20109"],"award-info":[{"award-number":["2023\/17711\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1\u2010related biomarkers in ACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search was conducted across multiple databases. Inclusion criteria comprised studies examining NOTCH1\u2010related features at ACC diagnosis and their relation with survival outcomes. Meta\u2010analysis was performed on studies sharing similar methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies met the eligibility criteria. NOTCH1 mutational status, Notch1 immunoexpression, and NICD1 immunoexpression were associated either with overall, disease\u2010free or progression\u2010free survival. Methodological disparities hindered integration of results. Meta\u2010analyses of HRs were conducted with 2 studies for each index factor, revealing a 2.31\u2010fold increased risk of death for primary ACC cases with NOTCH1 mutations, a 2.6\u2010fold increased risk of death for those exhibiting positive NICD1 expression and a 1.91\u2010fold heightened risk of disease recurrence for cases with high Notch1 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This comprehensive review underscores the prognostic relevance of NOTCH1 in ACC, indicating its potential as a valuable risk stratification tool.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70028","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T01:29:32Z","timestamp":1754962172000},"page":"647-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deciphering\n                    <scp>NOTCH1<\/scp>\n                    as a Biomarker in Adenoid Cystic Carcinoma: Insights From a Systematic Review With Meta\u2010Analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Isabela de Sousa","family":"Slivar","sequence":"first","affiliation":[{"name":"Department of Dentistry School of Dentistry, Universidade de S\u00e3o Paulo (FOUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno de Andrade","family":"Zanesco","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry, Universidade de S\u00e3o Paulo (FOUSP)  S\u00e3o Paulo 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