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Beck Anxiety and Depression Inventories were administered, and salivary cortisol and alpha\u2010amylase levels were determined. Descriptive analysis used the Mann\u2013Whitney U test to compare participants' responses and the Benjamini\u2010Hochberg Method to control the False Discovery Rate (FDR). Network analysis was performed using regularized partial correlation network models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant association was found between anxiety (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) scores and OLP. The \u201cshaky\/unsteady\u201d symptom was most central in the anxiety network for OLP patients, while \u201cfeelings of punishment\u201d and \u201cself\u2010criticism\u201d were central in the depression network. Weak correlations were observed between cortisol and alpha\u2010amylase in anxiety and depressive symptoms. Cortisol awekening response (CAR) had a negative correlation with alpha\u2010amylase awakening response (AAR) (\u22120.54), as like AAR and Faint\/lightheaded (\u22120.57) in anxiety network. Anxiety network structures did not differ between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.18), but the depression network was more connected in controls than in OLP cases (overall strength 69.29 vs. 27.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals the distinct network structures of anxiety and depression symptoms in OLP patients, highlighting a new methodological approach to exploring symptom configurations. When exploring the relationship with cortisol and alpha\u2010amylase, weak relationships were found between them. The findings may prompt further network studies involving biomarkers and their interaction with anxiety and depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70038","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T06:27:51Z","timestamp":1755584871000},"page":"872-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Network Analysis of Anxiety and Depression Symptoms in Individuals With Oral Lichen Planus and Evaluation of Salivary Biomarkers: A New Approach"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-8992","authenticated-orcid":false,"given":"Alessandra La\u00eds Pinho Valente","family":"Pires","sequence":"first","affiliation":[{"name":"Department of Health Sciences State University of Feira de Santana  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Mendon\u00e7a","family":"da Silva","sequence":"additional","affiliation":[{"name":"Arizona School of Dentistry and Oral Health A.T. Still University  Mesa Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Exact Sciences State University of Feira de Santana  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ynara Bosco","family":"de Oliveira Lima\u2010Arsati","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences State University of Feira de Santana  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Arsati","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences State University of Feira de Santana  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-265X","authenticated-orcid":false,"given":"Rodrigo Tripodi","family":"Calumby","sequence":"additional","affiliation":[{"name":"Department of Exact Sciences State University 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