{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:01:12Z","timestamp":1790895672012,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Vitamin D deficiency is common in hypophosphatasia (HPP) patients. However, its impact on oral health is unclear. Therefore, the purpose of this study was to investigate the relationship between Vitamin D levels and oral health in adults with hypophosphatasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this retrospective study, oral health and bone metabolism in HPP patients were examined. The Decayed\/Missing\/Filled Teeth (DMFT) index, clinical attachment level (CAL), probing pocket depth (PPD), and periodontal screening index (PSI) were among the metrics used to evaluate oral health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age of the 48 HPP patients in the study was 42.21 (\u00b115.78) years. A mean Vitamin D level of 29\u2009\u03bcg\/L was used to divide the participants into two groups. Compared to patients with Vitamin D levels above 29\u2009\u03bcg\/L, those with levels below this threshold showed noticeably worse oral health, as evidenced by higher PSI, PPD, decayed tooth count, and periodontitis severity index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results imply that adults with HPP who have low Vitamin D levels have worse oral health. To potentially improve oral health, it is crucial to diagnose and treat Vitamin D deficiency in HPP patients, as it is a known risk factor for periodontitis in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.70039","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T01:31:48Z","timestamp":1754962308000},"page":"798-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Vitamin D Level on Oral Health Status in Adult Hypophosphatasia"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-9775","authenticated-orcid":false,"given":"Florian","family":"Dudde","sequence":"first","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Periodontics, Preventive and Restorative Dentistry University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Fildebrandt","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kock","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Petz","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Smeets","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gosau","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beikler","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Barvencik","sequence":"additional","affiliation":[{"name":"Department of Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102021\u2010207426"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359\u20103997000000626"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13718"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmd2.12307"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010024\u201005809\u2010w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8594"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.01.024"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2022.06.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2023.116849"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13083"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051471"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010023\u201006844\u20101"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn022"},{"key":"e_1_2_12_15_1","unstructured":"A. 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