{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:21Z","timestamp":1772160741197,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral and plunging ranulas require effective treatment strategies to minimize recurrence; yet no consensus exists on the most effective approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review evaluated several treatments for the recurrence of oral and plunging ranulas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A comprehensive search was conducted in five bibliographic databases and gray literature. Randomized and non\u2010randomized studies were included if they investigated treatment approaches for oral or plunging ranulas. Two independent reviewers screened studies, extracted data, and assessed the risk of bias. The primary outcome was recurrence of (1) oral and (2) plunging ranula. For each type of ranula, a random\u2010model frequentist network meta\u2010analysis (NMA) was established for seven treatment strategies: enucleation, micromarsupialization, marsupialization, marsupialization with packing, partial sublingual gland excision, sublingual gland excision, and sublingual gland excision plus submandibular gland excision. A minimal important difference (MID) and the GRADE approach for NMA were used for interpretation of data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen studies were included (all non\u2010randomized\u201414 for oral ranula and six for plunging ranula). No treatment demonstrated clear superiority in preventing recurrence. Certainty of evidence was low to very low for oral ranulas and very low for plunging ranulas, primarily due to the risk of bias, imprecision, and intransitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the low certainty of evidence, no single treatment can be considered superior to others. Future research should prioritize longer follow\u2010up randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70041","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:41:01Z","timestamp":1757378461000},"page":"934-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatments to Avoid Ranula Recurrence: A Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Marina Rocha Fonseca","family":"Souza","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5838","authenticated-orcid":false,"given":"Mois\u00e9s Willian Aparecido","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP), Piracicaba, S\u00e3o Paulo, Brazil; Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Rayra","family":"Martins\u2010Chaves","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences of Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-2262","authenticated-orcid":false,"given":"Rachel","family":"Alvarenga\u2010Brant","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-3374","authenticated-orcid":false,"given":"Bruno","family":"Chrcanovic","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Ge","sequence":"additional","affiliation":[{"name":"Evidence\u2010Based Social Science Research Center, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honghao","family":"Lai","sequence":"additional","affiliation":[{"name":"Evidence\u2010Based Social Science Research Center, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Faculty of Medical Sciences of Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-3226","authenticated-orcid":false,"given":"Carolina Castro","family":"Martins\u2010Pfeifer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21326"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.04.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199801)20:1<63::AID-HED10>3.0.CO;2-Q"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.03.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23324"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14865"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/28498.10622"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2021.03.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22212"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537\u2010198803000\u201000011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.102771"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20291"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2019.45.6.357"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2019.06.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20102385"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010019\u201004976\u2010x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_10_20_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions, Version 6.5, Chapter\u00a010","author":"Higgins J. 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