{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T02:09:36Z","timestamp":1762826976179,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/07304\u20100","15\/10240\u20104","19\/09419\u20100"],"award-info":[{"award-number":["15\/07304\u20100","15\/10240\u20104","19\/09419\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melanoma affects skin and mucosa and can be particularly aggressive when the lesion is an advanced cutaneous tumor or located in the sinonasal or oral mucosa. Reprogramming of energy metabolism has been defined as a hallmark of cancer; so this study aimed to verify the expression of proteins related to metabolism and cellular proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemical analysis with antibodies adipophilin, FASN, GLUT\u20101, HIF\u20101\u03b1, and Ki\u201067 was performed in a series of 28 sinonasal melanomas (SM), 16 oral melanomas (OM), and 39 cutaneous melanomas (CM). For CM, 25 cases with matched lymph node metastases were analyzed, while 17 mucosal and 15 cutaneous melanocytic nevi served as controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SM showed an increased frequency of undifferentiated cells, necrotic areas, and marked expression of adipophilin in comparison to OM. In metastatic CM, a significant increase of FASN expression was detected. However, the frequency of expression of this protein was not significantly different between primary tumors and their metastasis. Concerning adipophilin expression in CM with or without metastasis, no significant difference was found, whereas the Ki\u201067 proliferative index was significantly lower in metastatic tumors. Benign melanocytic lesions showed lower expression of all markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SM and OM show marked differences in metabolic phenotype alterations since SM are more frequently positive for adipophilin. In CM, the marked expression of FASN in metastatic tumors suggests that these proteins probably contribute to disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70042","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T03:59:48Z","timestamp":1756353588000},"page":"953-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Heterogeneity Confers Differences in the Tumor Microenvironment of Aggressive Types of Melanomas"],"prefix":"10.1111","volume":"54","author":[{"given":"Juliana","family":"de Souza do Nascimento","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Diagnosis School of Dentistry, University of Campinas (FOP\/UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-6831","authenticated-orcid":false,"given":"Jo\u00e3o Figueira","family":"Scarini","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Diagnosis School of Dentistry, University of Campinas (FOP\/UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Said Abu","family":"Egal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Biorepository and Molecular Pathology University of Utah (UU)  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Brum","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department, Oncology Center (CEON), Fornecedores de Cana Hospital, Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Ribas Dias","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department, Oncology Center (CEON), Fornecedores de Cana Hospital, Piracicaba  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Schultz","family":"Amorim","sequence":"additional","affiliation":[{"name":"Institute of Pathological Anatomy  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel Martins Marinho","family":"Robim","sequence":"additional","affiliation":[{"name":"Institute of Pathological Anatomy  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00f3vis Ant\u00f4nio Lopes","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Pathology, A. C. Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Maria","family":"Peresi","sequence":"additional","affiliation":[{"name":"Department of Pathology, A. C. Camargo Cancer Center  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lucia Noronha","family":"Francisco","sequence":"additional","affiliation":[{"name":"Departament of Pathology, School of Dentistry University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-4547","authenticated-orcid":false,"given":"Felipe Paiva","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Departament of Pathology, School of Dentistry University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Otorhinolaryngology, A. C. 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