{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:57:43Z","timestamp":1788346663235,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibro\u2010osseous lesions (FOL) of the jawbones and cemento\u2010ossifying fibroma (COF) represent a heterogeneous group of lesions with overlapping histopathological features and variability in biological behavior. Thus, this study aimed to evaluate the clinical, radiographic, and histopathological characteristics of FOLs (cemento\u2010osseous dysplasia\u2014COD, fibrous dysplasia\u2014FD, ossifying fibroma\u2014OF) as well as COF, diagnosed at a reference center in oral pathology over 53\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sex, age, symptoms, clinical diagnosis, time of evolution, anatomical site, size of the lesion, and radiographic characteristics were collected from all cases of lesions previously diagnosed as FOLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 19\u2009600 cases of oral and maxillofacial lesions diagnosed at our center, 156 (0.8%) had a histological diagnosis of FOL, with COD being the most common (37.2%). Radiographically, most cases presented as unilocular lesions (64.3%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) with mixed radiolucency (53.8%). COD and COF frequently exhibited well\u2010defined borders. Additionally, 50% of COD cases displayed a cotton\u2010wool appearance, while half of FDs appeared as ground\u2010glass opacifications. Histopathologically, a significantly high frequency of lamellar bone was observed in all types of FOL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001). In contrast, peritrabecular clefting was significantly found in FDs, and cementum\u2010like tissue in CODs and COFs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Lesional bone fusing with the normal adjacent bone was more significantly observed in COD and FD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A definitive and accurate diagnosis of FOL is achievable when cases are individually investigated, and all clinical, radiographic, and histopathologic features are analyzed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70059","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T11:25:15Z","timestamp":1757503515000},"page":"1062-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical, Radiographic and Histopathological Analysis of Cemento\u2010Ossifying Fibromas and Fibro\u2010Osseous Lesions of the Oral and Maxillofacial Region: A 53\u2010Year Retrospective Study and Update of Current Concepts"],"prefix":"10.1111","volume":"54","author":[{"given":"Hannah Gil","family":"de Farias Morais","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"},{"name":"Multicampi School of Medical Sciences Federal University of Rio Grande do Norte  Caic\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Frota","family":"Colares","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edlia Raquel","family":"de Souto Medeiros","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-3588","authenticated-orcid":false,"given":"Caio C\u00e9sar","family":"da Silva Barros","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-7672","authenticated-orcid":false,"given":"Everton Freitas","family":"de Morais","sequence":"additional","affiliation":[{"name":"Graduate Program in Oral Biology, Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Cristina","family":"da Costa Miguel","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-5375","authenticated-orcid":false,"given":"Roseana","family":"de Almeida Freitas","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12797"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010021\u201001404\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010019\u201001094\u20102"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020238"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2021.04.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12531"},{"key":"e_1_2_11_8_1","volume-title":"WHO Classification of Tumours Series","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2023.152091"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2012.05.022"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.04.037"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2024.05.005"},{"key":"e_1_2_11_13_1","first-page":"251","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Mofty S. 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