{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:27:22Z","timestamp":1782743242720,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["19\/09419\u20100"],"award-info":[{"award-number":["19\/09419\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["20\/08431\u20104"],"award-info":[{"award-number":["20\/08431\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/11861\u20106"],"award-info":[{"award-number":["2022\/11861\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the clinicopathological features, survival rate, and potential prognostic markers of the jaws' primary intraosseous adenoid cystic carcinoma (PIACC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>MEDLINE\/PubMed, Scopus, and Embase searches were performed with the keywords \u201cadenoid cystic carcinoma,\u201d and \u201cjaw,\u201d or \u201cmaxilla,\u201d or \u201cmandible.\u201d We included articles that evaluated cases diagnosed as PIACC in jaws. Studies with insufficient demographic data, inconclusive histopathologic diagnosis, and appropriate follow\u2010up were excluded. The Joanna Briggs Institute tool was used to assess the risk of bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010five PIACC comprising 27 studies met the inclusion criteria. The mean age of the patients was 56.4\u2009\u00b1\u200919.6\u2009years with no sex predilection. PIACC showed a strong predilection for the mandible (69.1%), mainly in the posterior segment (40%). The patients presented symptoms in 87.3% of cases. Radiographically, PIACC presented as an ill\u2010defined radiolucent lesion (40%). Most cases showed a cribriform pattern (32.7%). PIACC with a solid growth pattern presented a lower disease\u2010free survival (DFS) (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.040). The 2\u2010 and 5\u2010year overall survival rates were 57.9% and 53.8%, respectively. Distant metastases were seen in 3.6% of the patients and were related to a lower DFS (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PIACC is a rare neoplasm of the jaws with an incidence in the fifth and sixth decades of life and no sex predilection. The posterior mandible was affected in most cases. Solid growth patterns and distant metastases are prognostic factors for a lower DFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70063","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T02:49:29Z","timestamp":1758682169000},"page":"32-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological Profile of Intraosseous Adenoid Cystic Carcinoma of the Jaws: A Systematic Review"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-8879","authenticated-orcid":false,"given":"Luccas","family":"Lavareze","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-6831","authenticated-orcid":false,"given":"Jo\u00e3o Figueira","family":"Scarini","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reydson Alcides","family":"de Lima\u2010Souza","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-7947","authenticated-orcid":false,"given":"Talita de Carvalho","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7547-660X","authenticated-orcid":false,"given":"Rog\u00e9rio de Oliveira","family":"Gondak","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Santa Catarina  Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Said Abu","family":"Egal","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Department of Pathology, School of Medicine University of Utah (UU)  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Viviane","family":"Mariano","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medical Sciences University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2000.19395"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.01.041"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22917"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.107058"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103792"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(92)90317\u2010s"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(55)90089\u2010x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.N71"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-01"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(90)90381\u20102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2012.02079.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.01.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2004.01060.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(90)90493\u2010l"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-009-9168-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12116"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770\u2010200012000\u201000026"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0278\u20102391(89)80112\u20100"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.07.025"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.06.029"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.038"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.11.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24984"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105213"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005\u2010020\u201000226\u20102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010020\u201003170\u20105"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197001)25:1<186::AID-CNCR2820250127>3.0.CO;2-H"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010022\u201001494\u2010x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53256"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099\u20102399(75)80086\u20100"},{"issue":"9","key":"e_1_2_10_32_1","first-page":"1327","article-title":"Comparison on CT Manifestations of Primary Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma","volume":"37","author":"Deng L.","year":"2021","journal-title":"Chinese Journal of Medical Imaging Technology"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.08.024"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01493"},{"key":"e_1_2_10_35_1","first-page":"164","volume-title":"World Health Organization Classification of Tumours","author":"Stenman G.","year":"2017"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23925"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2021.12.292"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901\u20105027(97)80008\u20102"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.07.001"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13480"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.103195"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2643"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24740"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21458"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103863"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103605"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:48:55Z","timestamp":1767746935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jop.70063"],"URL":"https:\/\/doi.org\/10.1111\/jop.70063","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"2023-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}