{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:03:16Z","timestamp":1775912596814,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021J30506"],"award-info":[{"award-number":["2021J30506"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["21A0242"],"award-info":[{"award-number":["21A0242"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Oral submucous fibrosis (OSF) is a chronic progressive disease characterized by fibrosis.\n                      <jats:italic>Panax notoginseng<\/jats:italic>\n                      saponins (PNS) are effective components of the traditional Chinese medicine\n                      <jats:italic>Panax notoginseng<\/jats:italic>\n                      and play an important role in the treatment of OSF. However, the underlying mechanism of action for this medicine remains unclear. The aim of this study was to explore the effects of ferroptosis in OSF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>The mice were divided into six groups. Mouth openings were detected. The buccal tissues were harvested for histomorphological analysis, western blot, and RT\u2010qPCR. The cells were harvested for CCK8 detection, western blot, RT\u2010qPCR, TEM, immunofluorescence, fluorescent probe, and colorimetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PNS improved mouth opening, alleviated tissue cell damage, and inhibited ferroptosis and fibrosis in OSF rat models. Our study found that ferroptosis is closely related to arecoline\u2010induced OSF and that PNS inhibits ferroptosis by upregulating glutathione peroxidase 4 (GPX4) to alleviate OSF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The research established OSF in\u00a0vivo and in\u00a0vitro, respectively, and the changes in the expression of fibrosis and ferroptosis\u2010related markers in these models were studied to provide a theoretical and experimental basis for the clinical prevention and treatment of OSF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70069","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:41:36Z","timestamp":1759999296000},"page":"107-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Panax notoginseng<\/i>\n                    Saponins Alleviate\n                    <scp>OSF<\/scp>\n                    by Inhibiting Ferroptosis Through\n                    <scp>GPX4<\/scp>\n                    Activation"],"prefix":"10.1111","volume":"55","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Sun","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zou","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7030-7969","authenticated-orcid":false,"given":"Lixiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-6979","authenticated-orcid":false,"given":"Qun","family":"Tang","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.825266"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51318"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90383-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12924"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291\u2010017\u20100689\u20107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040891"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"136","article-title":"Glutathione Peroxidase Revisited\u2010Simulation of the Catalytic Cycle by Computer\u2010Assisted Molecular Modelling","volume":"10","author":"Aumann K. 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