{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:22:54Z","timestamp":1787239374485,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["23038.005350\/2018\u201078"],"award-info":[{"award-number":["23038.005350\/2018\u201078"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312275\/2021\u20108"],"award-info":[{"award-number":["312275\/2021\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The antineoplastic drugs used in anticancer treatment regimens can induce changes in normal tissues, including salivary glands. This study evaluated the effects of clarified a\u00e7a\u00ed and photobiomodulation (PBM) on the oxidative biochemistry and microstructure of the parotid glands of rats with oral mucositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male rats (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954) were divided into five groups: Negative control (no mucositis); Positive control (mucositis without treatment); PBM; Clarified a\u00e7a\u00ed; and PBM\u2009+\u2009clarified a\u00e7a\u00ed. Oral mucositis was induced by intraperitoneal injection of 5\u2010fluorouracil on days 0 (60\u2009mg\/kg) and 2 (40\u2009mg\/kg). On days 3 and 4, bilateral scarification of the buccal mucosa was performed. On days 0 (negative controls), 8 and 10 (other groups), parotid glands were collected. To evaluate oxidative biochemistry, the following analyses were performed: Antioxidant capacity test against peroxyl radicals (ACAP), Lipid Peroxidation Assay (LPO), and Nitric oxide metabolite (NOx). Additionally, histopathological, histomorphometric, and histochemical analyses were performed. Statistical analysis was performed using two\u2010way ANOVA and Tukey's post\u2010test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clarified a\u00e7a\u00ed, alone or associated with photobiomodulation, increased antioxidant levels compared to the positive control on days 8 and 10. Regarding lipid peroxidation and nitric oxide metabolite, the positive control showed higher levels than the other groups. The morphological assessment showed that the clarified a\u00e7a\u00ed and photobiomodulation groups maintained similar structures of the parenchyma, stroma, and acini to the negative control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study results demonstrated that clarified a\u00e7a\u00ed and photobiomodulation conferred biochemical and structural protection to the parotid glands against chemotherapy\u2013induced damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70072","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:23:37Z","timestamp":1761301417000},"page":"120-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Clarified A\u00e7a\u00ed Supplementation and Photobiomodulation on the Parotid Glands of Rats Submitted to Chemotherapy"],"prefix":"10.1111","volume":"55","author":[{"given":"Wallacy Watson Pereira","family":"Melo","sequence":"first","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walessa Alana Bragan\u00e7a","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Karolina Martins","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 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Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah Ribeiro","family":"Fraz\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M\u00e1rio","family":"Matos\u2010Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadassa Helez Neves","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 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