{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:53:04Z","timestamp":1787453584168,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7254456"],"award-info":[{"award-number":["7254456"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170979"],"award-info":[{"award-number":["82170979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201091"],"award-info":[{"award-number":["82201091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M740140"],"award-info":[{"award-number":["2023M740140"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Excessive subchondral bone resorption is a typical manifestation in the early stage of osteoarthritis. This study is to verify whether and when intervening in subchondral bone could alleviate cartilage degeneration of temporomandibular joint osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Disc displacement without reduction was used to induce temporomandibular joint osteoarthritis. Alendronate\u00a0was\u00a0administered subcutaneously twice a week at a dosage of 60\u2009\u03bcg\/kg body weight for 1\u2009week by two intervention methods: early administration (1\u2009day after disc displacement without reduction surgery) and late administration (2\u2009weeks after disc displacement without reduction surgery). Micro\u2010\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      was used to assess subchondral bone mass and microstructure. Hematoxylin\u2013eosin staining, toluidine blue staining, tartrate\u2010resistant acid phosphatase staining, immunofluorescence staining, and Western blot were applied to evaluate histopathological changes of the condylar cartilage and subchondral bone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Early alendronate administration not only prevented subchondral bone resorption in early\u2010stage temporomandibular joint osteoarthritis, but also suppressed chondrocyte apoptosis, cartilage extracellular matrix degeneration, as well as excessive subchondral bone formation of condyle in late\u2010stage temporomandibular joint osteoarthritis. However, late alendronate administration had little effect on either subchondral bone or cartilage degenerative changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early inhibition of subchondral bone resorption could mitigate abnormal subchondral bone formation and condylar cartilage degeneration in late\u2010stage temporomandibular joint osteoarthritis, which might be a promising strategy for temporomandibular joint osteoarthritis treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70073","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:27:40Z","timestamp":1761218860000},"page":"133-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early Intervention of Subchondral Bone Resorption Mitigates Cartilage Degeneration in\n                    <scp>TMJOA<\/scp>"],"prefix":"10.1111","volume":"55","author":[{"given":"Meng\u2010Nan","family":"Cao","sequence":"first","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-9761","authenticated-orcid":false,"given":"Shi\u2010Yang","family":"Feng","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Chen","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Central Laboratory Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lei","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7049-9888","authenticated-orcid":false,"given":"Kai\u2010Yuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Disorders &amp; Orofacial Pain Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases  Beijing China"},{"name":"National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Beijing Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010022\u201000185\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519828731"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13138"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010021\u201005860\u2010y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.10.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.04.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.10.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2008.09.006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010218089"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk8402"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR\u201023\u20100133"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2938"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.158874"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20124"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.06.020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513501323"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100482\u20107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110376"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69493"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.05.009"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201075758\u20107"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.08.016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010015\u20100546\u20100"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802633"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.11.008"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0707onj"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.12.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23260"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107BOR\u20102016.vol30.0099"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1159393"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2022.111233"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.130"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201002246\u20107"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo7868"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021948\u20100"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2020.1870969"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:48:58Z","timestamp":1767746938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jop.70073"],"URL":"https:\/\/doi.org\/10.1111\/jop.70073","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOP.70073\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70073\/v2\/review1","asserted-by":"object"}]},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"assertion":[{"value":"2024-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}