{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:15:51Z","timestamp":1790784951140,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystadenoma of the salivary glands (CSG) is a rare benign, multicystic neoplasm, representing approximately 1%\u20134.7% of all benign salivary gland tumors. This study aimed to systematically review the clinicopathological data reported on case reports and case series of CSG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses statement. Comprehensive searches were performed across PubMed, Web of Science, Scopus, and Embase electronic databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 81 studies were included, encompassing 126 cases of CSG. A slight female predominance was observed (54.91%), with a mean patient age of 54.2\u2009\u00b1\u200921.5\u2009years. The median lesion size was 1.4\u2009\u00b1\u20091.6\u2009cm. The parotid gland was the most affected site (23.47%). Most cases were asymptomatic (86.58%), and nodular presentation was noted in 70.96%. Mucocele was the most suspected clinical diagnosis. Histopathologically, the papillary subtype was predominant (67.03%), with oncocytic cells prevailing, followed by columnar and cuboidal cell types. Of the 57 cases with available data on growth pattern, 38 were multicystic and 19 unicystic. Immunohistochemical analysis frequently involved the use of p63, MUC4, MUC1, and CK7. All cases were managed surgically, with a recurrence rate of 6.25%. The median follow\u2010up period was 12.1\u2009\u00b1\u200923.2\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CSG is a rare benign tumor that predominantly affects the parotid gland in female patients, typically presenting as a multicystic lesion. Surgical excision remains the treatment of choice, with a generally favorable prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70092","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T11:30:31Z","timestamp":1764847831000},"page":"280-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathological Features of Cystadenoma of the Salivary Glands: A Systematic Review"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-0567","authenticated-orcid":false,"given":"Selenne","family":"Romero\u2010Servin","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, National School of Higher Studies Leon Unit of the National Autonomous University of Mexico  Leon Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Leticia","family":"Mendoza\u2010Martinez","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, National School of Higher Studies Leon Unit of the National Autonomous University of Mexico  Leon Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7969","authenticated-orcid":false,"given":"Mario Alberto","family":"Alarc\u00f3n\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Molecular Biology and Medicine Program, University Center of Health Sciences University of Guadalajara (CUCS\u2010UdeG)  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Jessica","family":"Olalde\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Dental Specialities Unit, SEDENA  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell","family":"Bologna\u2010Molina","sequence":"additional","affiliation":[{"name":"Department of Diagnosis in Pathology and Oral Medicine, Molecular Pathology Area, School of Dentistry Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-5194","authenticated-orcid":false,"given":"Felipe Martins","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Diagnosis in Pathology and Oral Medicine, Molecular Pathology Area, School of Dentistry Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Head and Neck Tumours (WHO Classification of Tumours Series)","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_10_3_1","first-page":"39","article-title":"Uber das Cystadenoma papillare der grossen und Kleinen Speicheldrusen","volume":"55","author":"Skorpil F.","year":"1941","journal-title":"Frankfurter Zeitschrift f\u00fcr Pathologie"},{"key":"e_1_2_10_4_1","first-page":"814","article-title":"Oncocytic Papillary Cystadenoma of Parotid Gland","volume":"28","author":"Bajpai M.","year":"2018","journal-title":"Journal of the College of Physicians and Surgeons\u2013Pakistan"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2020.00367"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0273-z"},{"key":"e_1_2_10_7_1","first-page":"685","article-title":"Mucinous Cystadenoma: A Rare Entity","volume":"10","author":"Rai S.","year":"2013","journal-title":"Dental Research Journal"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000246"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-014-0656-2"},{"key":"e_1_2_10_10_1","article-title":"Cystadenoma in Retromolar Region: A Case Report","volume":"10","author":"Sheetal V. 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