{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:36:48Z","timestamp":1785832608855,"version":"3.56.0"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n \n Oral melanocytic neoplasms, such as oral melanocytic nevi (\n OMN<\/jats:styled-content>\n ), oral dysplastic nevi (\n ODN<\/jats:styled-content>\n ), atypical melanocytic proliferation (\n AMP<\/jats:styled-content>\n ), and oral mucosal melanoma (\n OMM<\/jats:styled-content>\n ), represent <\u20091% of oral lesions. They are composed of pigment\u2010producing cells with distinct biological behaviors. This study aimed to summarize the clinicopathological and molecular features of these lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Studies published in English (1950\u20132025) were retrieved from the\n PubMed<\/jats:styled-content>\n database and Web of Science Core Collection. All articles presenting clinicopathological and molecular outcomes of\n OMN<\/jats:styled-content>\n ,\n ODN<\/jats:styled-content>\n ,\n AMP<\/jats:styled-content>\n , and\n OMM<\/jats:styled-content>\n were included. A narrative summary was created to describe the findings.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n OMN<\/jats:styled-content>\n and\n OMM<\/jats:styled-content>\n are well\u2010described from a clinicopathological perspective. However,\n ODN<\/jats:styled-content>\n and\n AMP<\/jats:styled-content>\n remain scarcely documented. The genetic landscape of\n OMN<\/jats:styled-content>\n suggests a limited role for driver mutations in\n \n BRAF<\/jats:italic>\n <\/jats:styled-content>\n or\n \n GNAQ<\/jats:italic>\n <\/jats:styled-content>\n , which promote the proliferation of pigmented\u2010producing cells, often insufficient for malignancy.\n OMM<\/jats:styled-content>\n exhibits a distinct molecular profile characterized by a scarcity of\n MAPK<\/jats:styled-content>\n mutations and numerous copy\u2010number changes, as well as amplifications and chromosomal rearrangements. In contrast, no genetic data are available for\n ODN<\/jats:styled-content>\n and\n AMP.<\/jats:styled-content>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Oral melanocytic neoplasms are rare and have distinct clinicopathological features. Despite this, a gap exists in molecular data regarding\n ODN<\/jats:styled-content>\n and\n AMP<\/jats:styled-content>\n . Conversely,\n OMN<\/jats:styled-content>\n and\n OMM<\/jats:styled-content>\n have distinct profiles; in particular, the latter may benefit modestly from tyrosine kinase inhibitor treatment, as\n \n KIT<\/jats:italic>\n <\/jats:styled-content>\n and\n \n BRAF<\/jats:italic>\n <\/jats:styled-content>\n mutations are sensitive to imatinib and vemurafenib, respectively.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.70094","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:22:04Z","timestamp":1765603324000},"page":"429-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral Melanocytic Neoplasms: A Narrative Review"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8339-9421","authenticated-orcid":false,"given":"J.","family":"Maldonado\u2010Mendoza","sequence":"first","affiliation":[{"name":"Health Care Department Universidad Aut\u00f3noma 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