{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:31:11Z","timestamp":1775795471338,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This research aimed to investigate the topical effect of Resveratrol (RV) loaded on chitosan nanoparticles (CS\u2010NP) on chemically induced epithelial dysplasia in the hamster buccal pouch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      35 Syrian hamsters were used in this study; they were divided into 4 groups. Group A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) was the negative control group. 7,12\u2010dimethylbenzo anthracene (DMBA) was applied topically for 6\u2009weeks to induce oral epithelial dysplasia in the remaining 30 animals, then they were divided into group B (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) as the positive control group, group C (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) animals received CS\u2010NP (0.85\u2009mg\/100\u2009L) topically, and group D (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) animals received RV\u2010CS\u2010NP (0.85\u2009mg\/100\u2009L) topically for another 6\u2009weeks. Serial sections of the buccal pouches from all animals were examined histologically, and immunohistochemical (IHC) detection of the Bcl\u20102 gene expression was assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that treatment with RV loaded on CS\u2010NPs had significantly reduced the incidence of epithelial dysplastic lesions induced by the carcinogen. Data analysis showed statistically significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the expression levels of Bcl\u20102 through IHC between the treatment and positive control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Topical resveratrol\u2010loaded chitosan nanoparticles are promising chemopreventive therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70102","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:06:31Z","timestamp":1766484391000},"page":"495-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Topical Application of Resveratrol Loaded Chitosan Nanoparticles on Chemically Induced Epithelial Dysplasia in Hamster Pouch"],"prefix":"10.1111","volume":"55","author":[{"given":"Hadeel","family":"Sirageldeen","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry Suez Canal University  Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafaa","family":"El\u2010Hossary","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry Suez Canal University  Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A.","family":"Swidan","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry Suez Canal University  Ismailia 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