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This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the genetic mechanisms involved in their development and progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was performed following the PRISMA\u2010ScR guidelines. Studies included observational research, case reports, and systematic reviews focusing on molecular alterations in oral and maxillofacial OS. A comprehensive search was conducted across four databases, and findings were synthesized and categorized by molecular characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 20 studies involving 68 maxillofacial OS cases were included. The average patient age was 39.4\u2009years, with a slight male predominance. The mandible was the most commonly affected site, and chondroblastic OS was the most frequent histological subtype. Genetic alterations were predominantly observed in the\n                      <jats:italic>TP53<\/jats:italic>\n                      gene, along with alterations in\n                      <jats:italic>MDM2<\/jats:italic>\n                      ,\n                      <jats:italic>CDK4<\/jats:italic>\n                      , and other genes. Treatment primarily involved surgery, with or without chemotherapy. Local recurrence occurred in 11.1% of cases, and distant metastases in 16%. At the final follow\u2010up, 69.7% of patients were alive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study emphasizes the value of molecular techniques in improving the diagnosis and management of maxillofacial OS. However, further research is needed to fully understand the molecular complexity and optimize therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70103","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:24:09Z","timestamp":1765603449000},"page":"439-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review"],"prefix":"10.1111","volume":"55","author":[{"given":"Iara Vieira","family":"Ferreira","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"},{"name":"Pathology Department, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-6960","authenticated-orcid":false,"given":"Reydson Alcides","family":"de Lima\u2010Souza","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"},{"name":"Pathology Department, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5838","authenticated-orcid":false,"given":"Mois\u00e9s Willian Aparecido","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School State University of Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"},{"name":"Pathology Department, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Takahiro","family":"Chone","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Antolini\u2010Tavares","sequence":"additional","affiliation":[{"name":"Pathology Department, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albina","family":"Altemani","sequence":"additional","affiliation":[{"name":"Pathology Department, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Viviane","family":"Mariano","sequence":"additional","affiliation":[{"name":"Pathology Department, School of Medical Sciences State University of Campinas (UNICAMP)  Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Classification of Tumours Editorial Board. 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