{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:16:21Z","timestamp":1778127381096,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The cardiometabolic burden of oral candidiasis (OC) is yet to be thoroughly elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the risk of long\u2010term cardiovascular and metabolic outcomes in patients with OC relative to those with two other common oral conditions: herpes simplex virus (HSV) infections and recurrent aphthous stomatitis (RAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A global retrospective cohort study comprised two analyses comparing patients with OC to those with HSV and RAS. The study groups were compared regarding the risk of 11 different cardiovascular and four metabolic outcomes. Propensity score matching was performed to optimize inter\u2010group comparability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Relative to those with HSV infections, patients with OC were found to experience a higher risk of stroke (HR, 1.78; 95% CI, 1.65\u20131.92), sudden cardiac death (HR, 2.46; 95% CI, 2.14\u20132.82), congestive heart failure (CHF; HR, 1.92; 95% CI, 1.80\u20132.06), hypertension (HR, 1.56; 95% CI, 1.50\u20131.62), hyperlipidemia (HR, 1.18; 95% CI, 1.13\u20131.24), type\u20102 diabetes mellitus (DM; HR, 1.72; 95% CI, 1.63\u20131.81), and obesity (HR, 1.32; 95% CI, 1.27\u20131.38). Compared to RAS, OC demonstrated an elevated risk of myocardial infarction (HR, 1.47; 95% CI, 1.40\u20131.54), stroke (HR, 1.30; 95% CI, 1.25\u20131.36), pulmonary embolism (HR, 2.23; 95% CI, 2.11\u20132.35), peripheral vascular disease (HR, 1.35; 95% CI, 1.29\u20131.41), atrial fibrillation (HR, 1.61; 95% CI, 1.55\u20131.68), CHF (HR, 1.79; 95% CI, 1.73\u20131.86), hyperlipidemia (HR, 1.36; 95% CI, 1.33\u20131.40), DM (HR, 1.44; 95% CI, 1.40\u20131.48), and obesity (HR, 1.30; 95% CI,1.27\u20131.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OC is associated with an elevated risk of cardiometabolic outcomes. Physicians managing patients with OC should be aware of these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70105","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:28:11Z","timestamp":1767659291000},"page":"539-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Risk of Cardiometabolic Conditions Among Patients With Oral Candidiasis: A Global Large\u2010Scale Population\u2010Based Study"],"prefix":"10.1111","volume":"55","author":[{"given":"Samer","family":"Kridin","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences, Galilee Medical Center  Nahariya Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala","family":"Karayanni Matanis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences, Galilee Medical Center  Nahariya Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idan","family":"Redenski","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences, Galilee Medical Center  Nahariya Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7643-0061","authenticated-orcid":false,"given":"Mariam","family":"Abdelghaffar","sequence":"additional","affiliation":[{"name":"School of Medicine, Royal College of Surgeons in Ireland  Manama Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Srouji","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Galilee College of Dental Sciences, Galilee Medical Center  Nahariya Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Skin Research Laboratory Galilee Medical Center  Nahariya Israel"},{"name":"L\u0171beck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MCNA.2014.08.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.02.022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7020079"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.922.455"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.12.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908\u2010006\u20100057\u2010x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20109668.116991"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1600\u20100757.2000.2230111.X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010013\u20101181\u20102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IPRP.S133088"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163879"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2007.01439.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp054630"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.2007.00586.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1101398"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.11.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11\u201006\u20100392"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2630865"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102634"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ATHEROSCLEROSIS.2013.08.020"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.10.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/JOP.13499"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6695"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20109987.12803"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218684"}],"container-title":["Journal of Oral Pathology &amp; 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