{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:17:51Z","timestamp":1787311071978,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiotherapy\u2010induced malignancies are well\u2010documented, but the clinicopathological profile and prognostic factors of radiation\u2010induced oral squamous cell carcinoma (R\u2010OSCC) remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present review was conducted in accordance with the PRISMA guidelines and has been registered in the PROSPERO (registration number CRD42024560015). A comprehensive search was performed across electronic databases and gray literature sources. The risk of bias was assessed using the JBI tool. Meta\u2010analysis was performed with Review Manager 5.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five cohort studies were included (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009310), with four pooled in a meta\u2010analysis. R\u2010OSCC was significantly associated with tongue tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and early clinical stages (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Negative perineural invasion was linked to sporadic OSCC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008). Smoking (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008) and radiotherapy (RT) history (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001) were associated with decreased overall survival (OS), while RT history also reduced disease\u2010specific survival (DSS) in R\u2010OSCC patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>R\u2010OSCC predominantly affects the tongue, is diagnosed in early stages, and the history of RT is associated with reduced OS and DSS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70106","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T13:39:02Z","timestamp":1767101942000},"page":"448-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological Analysis and Survival Outcomes of Radiation\u2010Induced Oral Squamous Cell Carcinoma: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0750-7181","authenticated-orcid":false,"given":"Anne Evelyn Oliveira","family":"Moura","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, Semiology and Pathology Areas Piracicaba Dental School, University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Isabelly","family":"Rodrigues\u2010Fernandes","sequence":"additional","affiliation":[{"name":"Oral Pathology Unit, Department of Clinic and Preventive Dentistry Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0307-4991","authenticated-orcid":false,"given":"Ana Gabriela Costa","family":"Normando","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Semiology and Pathology Areas Piracicaba Dental School, University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Machado","family":"Farias","sequence":"additional","affiliation":[{"name":"Oral Pathology Unit, Department of Clinic and Preventive Dentistry Universidade Federal de Pernambuco  Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0065","authenticated-orcid":false,"given":"M\u00e1rcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Semiology and Pathology Areas Piracicaba Dental School, University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-4911","authenticated-orcid":false,"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Semiology and Pathology Areas Piracicaba Dental School, University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, Semiology and Pathology Areas Piracicaba Dental School, University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"de Abreu Alves","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Stomatology A.C. 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