{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:53:56Z","timestamp":1790286836503,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Papilliferous keratoameloblastoma (PKA) is an exceptionally rare variant of conventional ameloblastoma, marked by papilliferous epithelial projections and prominent keratinization within an ameloblastomatous framework. Because of its rarity and overlap with other keratinizing odontogenic tumours, PKA is often overlooked and is not recognised in the current WHO classification. Limited awareness and inconsistent terminology contribute to diagnostic uncertainty and may affect clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This review critically analysed all published PKA cases to describe their clinical, radiographic and histopathological features, evaluating whether PKA should be regarded as a distinct clinicopathological entity or a histological subtype of conventional ameloblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was performed to identify all English\u2010language reports of PKA. Extracted data included demographics, clinical presentation, radiographic findings, histopathology, treatment and outcomes. The information was synthesised and descriptively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven cases of PKA were included. Patients ranged from 18 to 76\u2009years (mean age: 50.4\u2009years), with a male predominance. All lesions involved the right mandible. Clinically, most patients presented with slow\u2010growing mandibular swellings, occasionally accompanied by pain or mucosal changes. Radiographs most often show multilocular radiolucencies with buccolingual expansion or cortical perforation. Histopathology consistently reveals classic ameloblastomatous epithelium with squamous metaplasia, keratin pearl formation, and distinctive papilliferous projections lining cystic spaces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The uniform histopathological pattern observed across reported cases supports recognising PKA as a distinct histopathological subtype of conventional ameloblastoma. Its formal inclusion in odontogenic tumour classification appears justified, although further molecular and clinicopathological studies are needed to better define its biological behaviour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70115","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:22:17Z","timestamp":1767421337000},"page":"511-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Papilliferous Keratoameloblastoma (PKA): Is It a Different Clinicopathological Entity or Histological Subtype of Conventional Ameloblastoma?"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-4307","authenticated-orcid":false,"given":"Yet Ching","family":"Goh","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry Universiti Malaya  Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell","family":"Bologna\u2010Molina","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Diagnostic in Oral Pathology and Oral Medicine Department School of Dentistry, Universidad de la Republica (UDELAR)  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-9694","authenticated-orcid":false,"given":"Kelly","family":"Magliocca","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-667X","authenticated-orcid":false,"given":"Willie","family":"van Heerden","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral and Maxillofacial Pathology School of Dentistry, University of Pretoria  Pretoria South Africa"},{"name":"PathCare Vermaak Histopatology Laboratory  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-7824","authenticated-orcid":false,"given":"Liam","family":"Robinson","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral and Maxillofacial Pathology School of Dentistry, University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-3923","authenticated-orcid":false,"given":"Elizabeth Ann","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Atlanta Oral Pathology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-5224","authenticated-orcid":false,"given":"Haizal Mohd","family":"Hussaini","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"School of Dentistry, University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-3335","authenticated-orcid":false,"given":"Merva","family":"Soluk\u2010Tekkesin","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral Pathology, Faculty of Dentistry Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-3265","authenticated-orcid":false,"given":"Madhu","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Diagnostic Sciences Texas A&amp;M University  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-2333","authenticated-orcid":false,"given":"Marilena","family":"Vered","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Pathology Sheba Medical Center, Tel Hashomer  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4615-2264","authenticated-orcid":false,"given":"Akinyele Olumuyiwa","family":"Adisa","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral Pathology, Faculty of Dentistry, College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-8760","authenticated-orcid":false,"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral Pathology, Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Department of Oral Surgery and Pathology School of Dentistry, Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Faculty of Medical Science of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7873-0877","authenticated-orcid":false,"given":"Keith David","family":"Hunter","sequence":"additional","affiliation":[{"name":"Members of International Consortium on Odontogenic Tumours"},{"name":"Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-7378","authenticated-orcid":false,"given":"Wanninayake Mudiyanselage","family":"Tilakaratne","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry Universiti Malaya  Malaysia"},{"name":"Members of International Consortium on Odontogenic Tumours"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00470.x"},{"key":"e_1_2_9_3_1","volume-title":"Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_9_4_1","volume-title":"Oral and Maxillofacial Pathology","author":"Neville B. W.","year":"2016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(76)80020-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690201000210"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/706128"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00887.x"},{"issue":"6","key":"e_1_2_9_9_1","first-page":"ZD08","article-title":"Papilliferous Keratoameloblastoma of the Mandible\u2014A Rare Case Report","volume":"10","author":"Konda P.","year":"2016","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_42_17"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijabmr.IJABMR_136_16"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_714_21"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(94)00037-5"},{"issue":"2","key":"e_1_2_9_14_1","first-page":"253","article-title":"Analysis of Demographic Differences According to Histomorphological Subtypes of 1312 Cases of Ameloblastoma","volume":"47","author":"Siriwardena B. S. M. S.","year":"2025","journal-title":"Malaysian Journal of Pathology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.04.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13228"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.11.032"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002325"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.70115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:43:00Z","timestamp":1778125380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jop.70115"],"URL":"https:\/\/doi.org\/10.1111\/jop.70115","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"assertion":[{"value":"2025-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}