{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:14:37Z","timestamp":1783307677494,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a chronic T\u2010cell\u2010mediated immune disease of unknown aetiology. MicroRNA (miRNAs) are short non\u2010coding RNAs capable of regulating mRNA and may have roles in T\u2010cell\u2010related diseases. The aim of this study was to investigate the profile of miRNAs in OLP patients and its interaction with potential target genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Total RNA was extracted from fresh frozen biopsies from 24 patients with OLP and 8 control patients. The NanoString Counter Analysis System was used to analyse total RNA samples for differential miRNA expression. NanoString expression was confirmed by RT\u2010qPCR analysis. Genes potentially targeted by upregulated and downregulated miRNAs were identified, and RT\u2010qPCR was employed to investigate the expression of target genes in OLP and controls. Probability values &lt;\u20090.05 were considered statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NanoString analysis showed that eight miRNAs, miR\u2010155, miR\u2010146a, miR\u20103195, miR\u2010342, miR\u20104516, miR\u201021, miR\u201029a and miR\u2010193 were upregulated in OLP tissues. Contrarily, the other eight miRNAs, miR\u2010221, miR\u2010200b, miR\u2010149, miR\u2010205, miR\u201027b, miR\u201095, miR\u2010127b, miR\u201095, miR\u2010206 were downregulated in OLP tissues. NanoString findings have been confirmed by RT\u2010qPCR results for four upregulated miRNAs, miR\u2010155, miR\u2010146a, miR\u201029a and miR\u2010342, and one downregulated miRNA, namely miR\u2010205. The expression of two target genes, namely MYC for miR\u201029a and interleukin\u201024 (IL\u201024) for miR\u2010205, was found to negatively correlate with the respective miRNA. This suggests that MYC and IL\u201024 could be regulated by the above miRNAs in OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The work presented in this study suggests that miRNAs could be involved in both the immunopathogenesis and malignant transformation of OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70122","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:16:26Z","timestamp":1770182186000},"page":"642-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Expression and Potential Role of Micro\n                    <scp>RNAs<\/scp>\n                    in Oral Lichen Planus"],"prefix":"10.1111","volume":"55","author":[{"given":"Mousa Ali","family":"Heba","sequence":"first","affiliation":[{"name":"Biosciences Institute Newcastle University  Newcastle upon Tyne UK"},{"name":"Oral Medicine Department, School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resteu","family":"Anastasia","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Andreas","sequence":"additional","affiliation":[{"name":"Biosciences Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrozzo","family":"Marco","sequence":"additional","affiliation":[{"name":"Oral Medicine Department, School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"},{"name":"NIHR Biomedical Research Centre Newcastle Univerity  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12260"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496\u2010014\u20100022\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022\u2010202X.2003.22108.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603023"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.011"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2017.1373901"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100714.2003.00077.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S369304"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2011.01869.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5502"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.05.513"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"316","article-title":"Evaluation of the miRNA\u2010146a and miRNA\u2010155 Expression Levels in Patients With Oral Lichen Planus","volume":"14","author":"Ahmadi\u2010Motamayel F.","year":"2017","journal-title":"Iranian Journal of Immunology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4068"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010291"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16935"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010011\u20101197\u2010x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100714.2003.00125.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.08.011"},{"key":"e_1_2_11_21_1","first-page":"103","volume-title":"Advances in Experimental Medicine and Biology","author":"Kunz M.","year":"2013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003192\u20104"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12303"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13196"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.12.003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020627"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.009"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059\u2010013\u20102154\u20107"}],"container-title":["Journal of Oral Pathology &amp; 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