{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:00:05Z","timestamp":1784808005424,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sclerosing odontogenic carcinoma (SOC) is a rare intraosseous neoplasm defined by the World Health Organization as a locally aggressive tumor with \u201cno metastatic potential\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review provides a critical evaluation of the biological behavior, clinicopathologic features, and clinical management of SOC cases, with a particular focus on neural invasion and cellular proliferation scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature was performed using the Pubmed and Scopus databases to identify all published English\u2010language reports of SOC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis of 22 reported cases revealed that SOC predominantly affects the mandible in middle\u2010aged adults, typically presenting as a radiolucent lesion associated with cortical resorption. Histopathologically, perineural invasion was identified in 77.3% of cases and revealed a wide range of Ki\u201067 expression (1%\u2013%30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This challenging entity exhibits a spectrum of malignant potential, and the current classification standard of \u201cno metastatic potential\u201d requires revision. In cases exhibiting diverse biological behaviors, the Ki\u201067 proliferation score can be used an ancillary marker for risk stratification; higher rates (e.g., &gt;\u200910%\u201315%) may be associated with aggressive local invasion and metastatic events. Further molecular studies on aggressive \u201cmetastatic\u201d cases are imperative to allow for identification of definitive markers that can establish SOC as a distinct entity and provide a rational basis for risk assessment and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70125","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:40:12Z","timestamp":1771486812000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sclerosing Odontogenic Carcinoma: A Review of a Challenging Entity in Malignant Odontogenic Classification With a Focus on Perineural Invasion and Cellular Proliferation"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-3335","authenticated-orcid":false,"given":"Merva","family":"Soluk\u2010Tekkesin","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith David","family":"Hunter","sequence":"additional","affiliation":[{"name":"Liverpool Head and Neck Centre, Molecular and Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell","family":"Bologna\u2010Molina","sequence":"additional","affiliation":[{"name":"Diagnostic in Oral Pathology and Oral Medicine Department, School of Dentistry Universidad de la Republica (UDELAR)  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Magliocca","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinyele Olumuyiwa","family":"Adisa","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry, College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-8760","authenticated-orcid":false,"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Ann","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathology, UDHS Oral Pathology Laboratory University of Pittsburgh School of Dental Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizal Mohd","family":"Hussaini","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-3265","authenticated-orcid":false,"given":"Madhu","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences, Oral &amp; Maxillofacial Pathology Texas A&amp;M University College of Dentistry  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Faculty of Medical Science of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie","family":"van Heerden","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-7378","authenticated-orcid":false,"given":"Wanninayake Mudiyanselage","family":"Tilakaratne","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817a8a58"},{"key":"e_1_2_12_3_1","first-page":"205","volume-title":"Odontogenic and Maxillofacial Bone Tumours. 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