{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:51:25Z","timestamp":1792122685397,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305891\/2024\u20103"],"award-info":[{"award-number":["305891\/2024\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["403444\/2023\u20103"],"award-info":[{"award-number":["403444\/2023\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This retrospective study investigates the interplay between epithelial\u2010mesenchymal transition (EMT) and immune response within the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Immunohistochemistry was conducted on OSCC specimens to evaluate the expression of podoplanin (PDP), E\u2010cadherin (CDH1), vimentin (VIM), fibronectin (FN), tenascin\u2010C (TNC), and vascular endothelial growth factor (VEGF). Cancer\u2010associated fibroblasts (CAFs) were identified by alpha\u2010smooth muscle actin (\u03b1\u2010SMA), and immune cells were quantified using CD66b for neutrophils and CD8 for T lymphocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher \u03b1\u2010SMA and moderate\u2010to\u2010strong VEGF expression were associated with reduced CDH1 and increased VIM and PDP expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), indicating an EMT\u2010like phenotype. Cases with elevated PDP\u2014also linked to high \u03b1\u2010SMA\u2014showed increased CD66b\n                      <jats:sup>+<\/jats:sup>\n                      cell density (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.072). VEGF expression additionally correlated with greater tumor thickness and depth of invasion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.059). Strong TNC expression was associated with reduced CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell infiltration in the tumor centre and increased CD66b\n                      <jats:sup>+<\/jats:sup>\n                      neutrophils (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.046). Strong FN expression was linked to a higher neutrophil\u2010to\u2010lymphocyte ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). Elevated CD66b\n                      <jats:sup>+<\/jats:sup>\n                      cell counts and a higher neutrophil\u2010to\u2010lymphocyte ratio were both significantly associated with poorer overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These exploratory findings suggest that CAFs serve not only as a marker of stromal activation but may also contribute to immunomodulation and invasive tumor phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70126","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T02:49:06Z","timestamp":1770950946000},"page":"660-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epithelial\u2010Mesenchymal Transition, Immune Response, and Extracellular Matrix Remodelling in Oral Cancer"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-0294","authenticated-orcid":false,"given":"Nicole","family":"Lonni","sequence":"first","affiliation":[{"name":"Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6990-9070","authenticated-orcid":false,"given":"Camilla Kammer","family":"Pereira","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8016-0951","authenticated-orcid":false,"given":"Amanda Maciel","family":"Costa","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5960-1217","authenticated-orcid":false,"given":"Aline Hsiao","family":"Bona","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-4809","authenticated-orcid":false,"given":"Andressa Fernanda Paza","family":"Miguel","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-5085","authenticated-orcid":false,"given":"Elis \u00c2ngela","family":"Batistella","sequence":"additional","affiliation":[{"name":"College of Dentistry, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-6010","authenticated-orcid":false,"given":"Daniella Serafin Couto","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-8771","authenticated-orcid":false,"given":"Elena Riet Correa","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center Federal University of Santa Catarina  SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J.","year":"2024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010023\u201000249\u2010w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2018.44.6.282"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13423"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201021\u20104370"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010023\u201001192\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030707"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013270"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.260244"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1582532"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014\u2010024\u201000488\u20107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13122"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110873"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oor.2024.100604"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12688"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12010020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666230404124229"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201020\u20100074"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010022\u201000353\u20106"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000\u2010015\u20100445\u20103"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120715"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.01.013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.04.029"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260800"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010020\u201001539\u2010x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.118"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050460"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.70126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T02:23:49Z","timestamp":1783304629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jop.70126"],"URL":"https:\/\/doi.org\/10.1111\/jop.70126","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOP.70126\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70126\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOP.70126\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}