{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:14:35Z","timestamp":1783307675997,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Doxorubicin (DOX) is a widely used chemotherapy drug, but its severe toxic effects, including inflammation and taste disturbances, limit its clinical use. This study examined the protective effects of vitamin D on DOX\u2010induced changes in tongue tissue and systemic inflammation in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight adult male Wistar Albino rats (10\u201312\u2009weeks old) were divided into four groups: Control, DOX, Vitamin D 5000\u2009+\u2009DOX, and Vitamin D 60\u2009000\u2009+\u2009DOX. Vitamin D3 was administered intraperitoneally either daily (5000\u2009IU\/kg) or 3\u2009days a week (60\u2009000\u2009IU\/kg) for 21\u2009days. DOX (18\u2009mg\/kg, intraperitoneally) was administered on days 19\u201321. Tongue tissues were analyzed for angiotensin\u2010converting enzyme 2 (ACE2) expression via immunohistochemistry, and serum cytokine levels (TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106) were measured using enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DOX treatment significantly increased ACE2 expression in tongue tissue compared with controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), accompanied by elevated serum inflammatory cytokine levels and reduced body weight. Vitamin D supplementation significantly attenuated DOX\u2010induced ACE2 upregulation and inflammatory cytokine elevations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, no clear dose\u2010dependent difference was observed between the two vitamin D regimens, as ACE2 expression did not differ significantly between the 5000\u2009IU\/kg and 60\u2009000\u2009IU\/kg groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOX administration is associated with increased ACE2 expression in tongue tissue and systemic inflammation in a rat model. Vitamin D supplementation mitigates these DOX\u2010induced alterations; however, within the tested dose range, no additional benefit of the higher vitamin D dose was demonstrated. These findings suggest a potential modulatory role of vitamin D on chemotherapy\u2010associated inflammatory and molecular changes, while highlighting the need for further mechanistic and functional studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70127","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T01:55:55Z","timestamp":1770861355000},"page":"650-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin\n                    <scp>D<\/scp>\n                    Modulates Doxorubicin\u2010Induced\n                    <scp>ACE2<\/scp>\n                    Expression and Pro\u2010Inflammatory Cytokines in the Rat Tongue"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-2799","authenticated-orcid":false,"given":"Mustafa Sami","family":"Demirsoy","sequence":"first","affiliation":[{"name":"Department of Oral and 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Istinye University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-3331","authenticated-orcid":false,"given":"Necla","family":"De\u011fer","sequence":"additional","affiliation":[{"name":"Department of Histology\u2010Embryology, Faculty of Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-6174","authenticated-orcid":false,"given":"Derya","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Department of Histology\u2010Embryology, Faculty of Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9799-6398","authenticated-orcid":false,"given":"Fadime","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine Tokat Gaziosmanpasa University  Tokat 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