{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:14:35Z","timestamp":1783307675015,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273017"],"award-info":[{"award-number":["82273017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Perineural invasion (PNI) is a pathological hallmark associated with tumor spread. Evidence suggested that PNI location (extratumoural vs. intratumoural) held prognostic significance in early\u2010stage oral squamous cell carcinoma (OSCC), whereas the prognostic impact of PNI extent (unifocal versus multifocal) remained to be elucidated. The primary aim of this study was to evaluate the prognostic relevance of PNI extent in early\u2010stage tongue squamous cell carcinoma (TSCC) characterized by worst pattern of invasion 4 (WPOI\u20104).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 130 patients with pT1\/T2 pN0\/Nx TSCC were included in this retrospective study, of whom 104 did not receive postoperative radiotherapy (PORT), while the remaining 26 underwent PORT. Based on the Yamauchi\u2013Kuratomi (YK) classification, WPOI\u20104 cases were further stratified into 4C\/4D and non\u20104C\/4D subtypes. Depth of invasion (DOI) was dichotomized using a 4\u2009mm threshold.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis revealed that both multifocal and unifocal PNI were significantly associated with disease\u2010free survival (DFS), whereas no meaningful association was observed with overall survival (OS). Compared to unifocal PNI (odds ratio [OR]\u2009=\u20095.504; 95% confidence interval (CI)\u2009=\u20091.994\u201315.188;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), multifocal PNI conferred an approximately fivefold increased risk of disease progression (OR\u2009=\u200927.009; 95% CI\u2009=\u20098.695\u201383.900;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In addition, multifocal PNI showed a notable correlation with DOI\u2009&gt;\u20094\u2009mm and 4C\/4D histology. Elective neck dissection (END) combined with postoperative radiotherapy (PORT) significantly reduced disease progression in PNI\u2010positive patients, particularly those with multifocal PNI (OR\u2009=\u20090.01; 95% CI\u2009=\u20090.002\u20130.051;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among patients who did not receive PORT, END showed limited benefit in multivariate analysis. However, after excluding cases with isolated local recurrence, END was associated with improved DFS in patients with cervical lymph node metastasis (CLNM) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support incorporating the extent of PNI into routine pathology reporting and suggest that END and PORT may be considered, particularly in cases of multifocal PNI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70133","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:54:42Z","timestamp":1774832082000},"page":"695-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifocal Perineural Invasion Predicts Poor Disease\u2010Free Survival in Early\u2010Stage Tongue Squamous Cell Carcinoma Exhibiting\n                    <scp>WPOI<\/scp>\n                    \u20104"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4499-0292","authenticated-orcid":false,"given":"Xiaoli","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-8760","authenticated-orcid":false,"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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