{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T03:14:33Z","timestamp":1783307673317,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["RED\u201000213\u201023"],"award-info":[{"award-number":["RED\u201000213\u201023"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["RED\u201000570\u201016"],"award-info":[{"award-number":["RED\u201000570\u201016"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Oral mucositis is a severe health and economic problem that occurs in about 40%\u201390% of patients undergoing cancer treatments. Systemic or topical application of\n                      <jats:sc>l<\/jats:sc>\n                      \u2010glutamine has been shown to improve mucosal healing and ameliorate oral mucositis (OM) symptoms according to clinical score systems. To further establish the beneficial effects of this amino acid, our study examined the actions of topical application of\n                      <jats:sc>l<\/jats:sc>\n                      \u2010glutamine on inflammation and mucosal healing markers in tongue lesions in mice treated with 5\u2010Fluorouracil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The animals received 3 doses of the chemotherapeutic agent (non\u2010consecutive days) at concentrations of 60, 40, and 40\u2009mg\/kg, respectively. Tongue lesions were made by acetic acid (bolus injection) on the ventral face. Ten mg\/50\u2009\u03bcL of\n                      <jats:sc>l<\/jats:sc>\n                      \u2010glutamine were applied at the site of the lesion in the treated group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) twice a day for 5\u2009days; the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) received filtered water. On day 6, the animals were euthanized, the tongues removed, and processed for inflammatory and fibrogenic markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The treatment decreased myeloperoxidase (MPO) and\n                      <jats:italic>N<\/jats:italic>\n                      \u2010acetyl\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010glucosaminidase (NAG) activities, tumor necrosis factor alpha levels (TNF\u2010\u03b1), and mast cell numbers at the site of the lesions. The amino acid was able to decrease the number of Ki\u201067 positive cells in the treated group. There was increased mucosal remodeling through collagen deposition in the treated group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Topical application of\n                      <jats:sc>l<\/jats:sc>\n                      \u2010glutamine acted on multiple axes of OM, modulating inflammation and tissue remodeling in immunosuppressed mice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70135","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:40:17Z","timestamp":1775551217000},"page":"705-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Beneficial Effects of Topical\n                    <scp>l<\/scp>\n                    \u2010Glutamine on Oral Mucositis in 5\u2010Fluorouracil\u2010Treated Mice"],"prefix":"10.1111","volume":"55","author":[{"given":"Juliana Francisca Grossi","family":"Heleno","sequence":"first","affiliation":[{"name":"Department of General Pathology, Biological Science Institute Federal University of Minas Gerais  Belo Horizonte Brazil"},{"name":"Department of Hospital Dentistry Benjamin Guimar\u00e3es Foundation, Hospital of Baleia  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"de Campos Fontes","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Biological Science Institute Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Cristine Cardoso","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Biological Science Institute Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Prokop Gon\u00e7alves","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Biological Science Institute Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iury Berckmann Freitas","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Biological Science Institute Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek William","family":"Gilroy","sequence":"additional","affiliation":[{"name":"Department of Ageing, Rheumatology &amp; Regenerative Medicine University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Passos","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Biological Science Institute, Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Peixoto","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Biological Science Institute Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1217993"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.08.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010020\u201001715\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1318"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20162"},{"issue":"1139","key":"e_1_2_11_7_1","first-page":"45","article-title":"Serum Levels of NFkappaB and Pro\u2010Inflammatory Cytokines Following Administration of Mucotoxic Drugs","volume":"7","author":"Logan R. 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