{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:19:42Z","timestamp":1791908382517,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the risk for oral squamous cell carcinoma (OSCC) among patients with oral lichen planus (OLP) or lichenoid lesions (OLL) and the possible risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Two hundred thirty\u2010nine OLP and 84 OLL patients diagnosed between years 1982 and 2017 were followed up to December 2023, diagnosis of an OSCC, or death. Potential demographic and clinical risk factors were compared, and a Cox proportional\u2010hazards model was used to investigate associations between time to OSCC onset and variables of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six OLP patients (2.5%; three females), in a mean follow\u2010up of 17.5\u2009years, and six OLL patients (7.1%; three females), in a mean follow\u2010up of 13.8\u2009years, developed OSCC. The annual MT rate was 0.14% for OLP and 0.5% for OLL. The mean time for OSCC development from OLP diagnosis was 11.4\u2009years and from OLL diagnosis 12\u2009years. Four OLP patients (67%; two females) developed OSCC in the mobile tongue, while in OLL patients OSCCs occurred at various sites. A potential association was observed between floor\u2010of\u2010mouth lesions in OLP and gingival or extraoral LP involvement in OLL and increased OSCC risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirms that both OLP and OLL patients are at a long\u2010term risk of OSCC, and the risk is higher for OLL patients. Site\u2010specific lesions in OLP and OLL were linked to increased OSCC risk, warranting confirmation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70139","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:39:41Z","timestamp":1776235181000},"page":"784-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of Malignant Transformation in Patients With Oral Lichen Planus or Lichenoid Lesions: A Retrospective Study of 323 Patients With a Minimum of 5\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-9013","authenticated-orcid":false,"given":"Mari","family":"Vehvil\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Selander","sequence":"additional","affiliation":[{"name":"Science Service Center Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine, Medical Research Center University of Oulu and Oulu University Hospital;  Oulu Finland"},{"name":"Department of Oral and Maxillofacial Diseases, Translational Immunology Program (TRIMM), iCAN Digital Precision Cancer Medicine Flagship University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Siponen","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Institute of Dentistry University of Eastern Finland  Kuopio Finland"},{"name":"Odontology Education Unit and Department of Oral and Maxillofacial Diseases Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13323"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3797"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.11.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.121"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.07.012"},{"key":"e_1_2_11_7_1","first-page":"32","article-title":"Sur un cas de lichen de Wilson gingival avec neoplasie voisine dans la region maxillaire","volume":"17","author":"Hallopeau H.","year":"1910","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Syphiligraphie"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12885"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1978.tb01879.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70033-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12996"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01221.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00341.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0302"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00139-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13812"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.23576"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.09.006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-074723"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18879"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2002.29.9.442"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70176-T"}],"container-title":["Journal of Oral Pathology &amp; 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