{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:46:23Z","timestamp":1785721583492,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to determine the clinical significance of mean vascular density (MVD) using the expression of CD105 (endoglein) to predict the 3\u2010 and 5\u2010year survival rates of oral squamous cell carcinoma (OSCC), as well as assess its value for predicting clinical outcomes of OSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 217 OSCC patients treated surgically between 2010 and 2015 were included. Immuno\u2010histochemistry for CD105 was performed, and MVD was quantified. The correlations of MVD with histopathological (HSPL) grade, the clinical Tumor Node Metastasis (TNM) stage, nodal status and survival were analyzed. Multivariate Cox proportional hazards regression analysis was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The MVD significantly increased with increasing HSPL grade from well\u2010differentiated OSCC to poorly\u2010differentiated OSCC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). MVD was significantly increased for advanced\u2010stage TNM cases (III\/IV) and metastatic cases when compared to early\u2010stage and non\u2010metastatic tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Survival analysis revealed an inverse relationship between MVD and both three\u2010 and five\u2010year disease\u2010free survival. Patients with low MVD had the highest disease\u2010free survival (3\u2009years: 96.2%, 5\u2009years: 92.7%), whereas those with high MVD had poor survival (3\u2009years: 34.0%, 5\u2009years: 27.9%). Multivariate Cox regression analysis confirmed MVD and HSPL grade as independent prognostic factors for overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An elevated MVD by CD105 expression is strongly correlated with aggressive HSPL features, stage, nodal metastasis, and poor prognosis in OSCC. In addition to prognostic information, CD105 has the potential to be a target for anti\u2010angiogenic strategies in OSCC indicating its potential use in clinical risk stratification and planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70142","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:02:26Z","timestamp":1776747746000},"page":"805-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance of\n                    <scp>CD105<\/scp>\n                    \u2010Assessed Angiogenesis in Relation to Survival and Clinicopathological Features of Oral Squamous Cell Carcinoma"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-7694","authenticated-orcid":false,"given":"Amol Ramchandra","family":"Gadbail","sequence":"first","affiliation":[{"name":"Department of Dentistry Government Medical College &amp; Hospital  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minal","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital Datta Meghe Institute of Higher Education &amp; Research (DMIHER), Sawangi (M)  Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit Ashok","family":"Tekade","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Modern Dental College and Research Centre  Indore Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8576-7897","authenticated-orcid":false,"given":"Alka","family":"Hande","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital Datta Meghe Institute of Higher Education &amp; Research (DMIHER), Sawangi (M)  Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-8292","authenticated-orcid":false,"given":"Monal","family":"Yuwanati","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospital Saveetha Institute of Medical and Technical Sciences, Saveetha University  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranali","family":"Nimonkar","sequence":"additional","affiliation":[{"name":"Department of Dentistry Government Medical College &amp; Hospital  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh M.","family":"Gondivkar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Government Dental College &amp; Hospital  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-0957","authenticated-orcid":false,"given":"Sachin","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital Dr. D.Y. Patil Vidyapeeth  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66658-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10258"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601452"},{"issue":"8","key":"e_1_2_12_5_1","first-page":"39","article-title":"Role of Angiogenesis Inhibitors in Cancer Treatment","volume":"15","author":"Ellis L. 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