{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:15:54Z","timestamp":1788315354433,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation damage severely impacts salivary gland function and cell survival, especially in head and neck radiotherapy. Tempol (TPL), a free radical scavenger, has shown protective effects against radiation damage. This research aimed to investigate the protective effects of TPL on radiation\u2010induced damage in Hs917.T cells and the submandibular gland (SMG) of C57BL\/6 mice, along with the mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Human parotid fibroblasts (Hs917.T) were pre\u2010treated with TPL and exposed to ionizing radiation (IR). Protective effects were evaluated using MTT, clonogenic survival assays, flow cytometry, and intracellular reactive oxygen species levels. In\u00a0vivo, C57BL\/6 mice were pre\u2010treated with TPL (275\u2009mg\/kg) and exposed to 15 gray (Gy). Effects were assessed by survival rates, body weight changes, histological analysis, and TUNEL staining. Changes in apoptosis\u2010related markers and \u03b2\u2010catenin signaling pathway were analyzed, and the role of TPL was verified using the \u03b2\u2010catenin inhibitor XAV939.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TPL pre\u2010treatment increased cell survival, reduced apoptosis, alleviated cell cycle arrest, and decreased intracellular superoxide and hydrogen peroxide levels in Hs917. T cells. In C57BL\/6 mice, pre\u2010treatment with TPL improved survival, mitigated weight loss, reduced SMG damage, and decreased apoptosis. TPL inhibited IR\u2010induced apoptosis by increasing Bcl\u20102 expression and decreasing Bax and caspase\u20109 levels. TPL exerted anti\u2010apoptotic and protective effects by upregulating the expression of \u03b2\u2010catenin, promoting its nuclear translocation, and inhibiting its phosphorylation. These protective effects of TPL were reversed by XAV939.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TPL exerted protective effects against IR\u2010induced damage in Hs917.T cells and the SMG of C57BL\/6 mice through activating the \u03b2\u2010catenin signaling pathway, inhibiting cell apoptosis, and alleviating oxidative stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70147","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:40:16Z","timestamp":1778812816000},"page":"895-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tempol Protects Against Radiation Injury in the Submandibular Gland Through the \u03b2\u2010Catenin Signaling Pathway"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5104-6342","authenticated-orcid":false,"given":"Jinfeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Gannan Medical University  Ganzhou China"},{"name":"Jiangxi \u201cFlagship\u201d Oncology Department of Synergy for Chinese and Western Medicine  Ganzhou China"},{"name":"Jiangxi Provincial Unit for Clinical Key Oncology Specialty Development  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Gannan Medical University  Ganzhou China"},{"name":"Jiangxi \u201cFlagship\u201d Oncology Department of Synergy for Chinese and Western Medicine  Ganzhou China"},{"name":"Jiangxi Provincial Unit for Clinical Key Oncology Specialty Development  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Gannan Medical University  Ganzhou China"},{"name":"Jiangxi \u201cFlagship\u201d Oncology Department of Synergy for Chinese and Western Medicine  Ganzhou China"},{"name":"Jiangxi Provincial Unit for Clinical Key Oncology Specialty Development  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhong","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9370-6743","authenticated-orcid":false,"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Ganzhou People's Hospital  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16061141"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061219"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.645207"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124095"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049570"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S510206"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00660"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.649793"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031446"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12061278"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03495-0"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02363-1"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14090871"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_421_18"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology14020185"},{"issue":"1","key":"e_1_2_14_17_1","first-page":"303","article-title":"The Effects of the Wnt\/\u03b2\u2010Catenin Signaling Pathway on Apoptosis in HeLa Cells Induced by Carbon Ion Irradiation","volume":"44","author":"Si J.","year":"2020","journal-title":"Oncology Reports"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0662"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0958"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2025.02.006"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087140"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217341"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1879"},{"key":"e_1_2_14_24_1","article-title":"Radioprotection by Tempol: Studies on Tissue Antioxidant Levels, Hematopoietic and Gastrointestinal Systems","volume":"10","author":"Ramachandran L.","year":"2023","journal-title":"International Journal 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