{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:46:28Z","timestamp":1785721588674,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral tongue squamous cell carcinomas (OTSCC) frequently metastasise via lymphatic vessels, thus lymphangiogenesis may enhance tumour cell dissemination by increasing tumour\u2010lymphatic interactions. The prognostic significance of lymphatic vessel density (LVD) and lymphatic vessel area (LVA) in OTSCC remains inconclusive. This study aimed to evaluate the association of tumour\u2010associated LVD and LVA with clinical outcomes and pathological characteristics in a homogenous OTSCC cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed tumour samples from 121 OTSCC patients using D2\u201040 immunohistochemical staining to visualise lymphatic vessels. We calculated mean LVD and LVA from five peritumoural hotspots per tumour and examined their relationships to clinical\u2010pathological data including 5\u2010year disease\u2010specific survival (DSS) using cross\u2010tabulation, Kaplan\u2013Meier, and Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High LVD was more prevalent in well\/moderately differentiated compared to poorly differentiated tumours (78.1% and 45.5%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). No significant associations were found between LVD or LVA and other clinical\u2010pathological variables. Neither low LVD nor LVA significantly impacted 5\u2010year DSS in univariate (HR\u2009=\u20090.65 CI: 0.32, 1.31; HR\u2009=\u20090.69, 95% CI: 0.34, 1.40, respectively) or multivariate analyses (HR\u2009=\u20090.75, 95% CI: 0.32, 1.76; HR\u2009=\u20090.54, 95% CI: 0.23, 1.25, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LVD and LVA did not predict prognosis in this OTSCC cohort. Further standardised studies investigating lymphatic vessels within the tumour microenvironment are necessary to better understand their role and potential prognostic significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70148","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:15:09Z","timestamp":1777533309000},"page":"837-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer"],"prefix":"10.1111","volume":"55","author":[{"given":"Ida Andersson","family":"Cronblad","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine Elise","family":"Warvik","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Clinical Pathology University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger\u2010Heidi","family":"Bjerkli","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Otorhinolaryngology Finnmark Hospital, Clinic Alta  Alta Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja Eriksson","family":"Steigen","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Clinical Pathology University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Uhlin\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Clinical Pathology University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0762-1240","authenticated-orcid":false,"given":"Synn\u00f8ve Norvoll","family":"Magnussen","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Hadler\u2010Olsen","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"The Public Dental Health Service Competence Centre of Northern Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Wirsing","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Clinical Pathology University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813477992"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24744"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1679-775720130317"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-014-0689-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6915a1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33309"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2013-0057"},{"key":"e_1_2_12_10_1","first-page":"98","volume-title":"Cancer in Norway 2023\u2014Cancer Incidence, Mortality, Survival and Prevalence in Norway","author":"Cancer Registry of Norway","year":"2024"},{"issue":"3","key":"e_1_2_12_11_1","first-page":"175","article-title":"Oral Squamous Cell Carcinoma With Metastasis to the Parotid Lymph Node","volume":"22","author":"Zhang W. 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