{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:15:58Z","timestamp":1788315358838,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>MicroRNAs (miRNAs) are small RNAs that have been associated with tumourigenesis and tumour progression and that play an important role in the pathogenesis of salivary gland neoplasms. The aim of this study was to evaluate the global miRNA expression profile in a sample of salivary gland neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cases of pleomorphic adenoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), adenoid cystic carcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and mucoepidermoid carcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) were studied by real\u2010time RT\u2010PCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The main up\u2010regulated miRNAs were hsa\u2010miR\u2010373, hsa\u2010miR\u2010675, hsa\u2010miR\u2010508, hsa\u2010miR\u20101290 and hsa\u2010miR\u2212483\u20103p, while hsa\u2010miR\u2010105 and hsa\u2010let\u20107f\u20101 were among the most down\u2010regulated miRNAs compared to the normal salivary gland. Hsa\u2010miR\u2010106b, hsa\u2010miR\u2010142\u20105p, hsa\u2010miR\u2010622, hsa\u2010miR\u2010642, hsa\u2010miR\u2010574\u20103p and hsa\u2010miR\u2010486 were significantly differentially expressed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) when each neoplasm and normal glandular tissue were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study described the global molecular signature of miRNAs in benign and malignant salivary gland neoplasms and provided preliminary evidence of miRNA dysregulation, suggesting a potential association between specific miRNA signatures and molecular pathways implicated in tumour progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70150","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:25:52Z","timestamp":1779755152000},"page":"906-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneity of\n                    <scp>miRNAs<\/scp>\n                    in Salivary Gland Neoplasms: An Exploratory Pilot Study"],"prefix":"10.1111","volume":"55","author":[{"given":"Dandara Andrade","family":"de Santana","sequence":"first","affiliation":[{"name":"Post\u2010Doctoral Fellow, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana Ramos","family":"Braga","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry and Health, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5057-4983","authenticated-orcid":false,"given":"Daniel Araki","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Institute of Health and Society Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-0483","authenticated-orcid":false,"given":"Patricia Ramos","family":"Cury","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry and Health, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Velasco Pond\u00e9","family":"de Sena","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry and Health, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Cal\u00f3","family":"de Aquino Xavier","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry and Health, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"},{"name":"Laboratory of Oral and Maxillofacial Pathology, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[{"name":"Pathology Division Rede D'or Hospital Network  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iguaracyra Barreto","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, Medical School Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Albuquerque","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"},{"name":"Center for Translational Research in Oncology, Cancer Institute of the State of S\u00e3o Paulo (ICESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health Feira de Santana State University  Feira de Santana Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-2668","authenticated-orcid":false,"given":"Cl\u00e1udia Malheiros","family":"Coutinho\u2010Camillo","sequence":"additional","affiliation":[{"name":"International Research Center A.C. Camargo Cancer Center  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Nunes","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry and Health, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"},{"name":"Laboratory of Oral and Maxillofacial Pathology, School of Dentistry Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25381"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.3.593"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2016.03.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.04.002"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.10.012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14061220"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210968"},{"key":"e_1_2_12_9_1","volume-title":"WHO Classification of Tumours, Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2423-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24298"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9150402"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.105"},{"key":"e_1_2_12_14_1","first-page":"4237","article-title":"Role of miR\u201021 in the Growth and Metastasis of Human Salivary Adenoid Cystic Carcinoma","volume":"17","author":"Yan F.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.157"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.019"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0523-z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154119"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-52"},{"key":"e_1_2_12_20_1","first-page":"3631","article-title":"MicroRNA\u2010675\u20103p Promotes Esophageal Squamous Cell Cancer Cell Migration and Invasion","volume":"18","author":"Xiao Q.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_21_1","first-page":"1481","article-title":"miR\u2010675 Promotes Colorectal Cancer Cell Growth Dependent on Tumor Suppressor DMTF1","volume":"19","author":"Yang X.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8950"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109352"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13516"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2101"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S262442"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495328"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06192-w"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.596574"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8913"},{"key":"e_1_2_12_31_1","first-page":"3551","article-title":"Identification of Key Tumorigenesis\u2010Related Genes and Their microRNAs in Colon Cancer","volume":"40","author":"Xie B.","year":"2018","journal-title":"Oncology Reports"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.70150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:58:05Z","timestamp":1788314285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jop.70150"],"URL":"https:\/\/doi.org\/10.1111\/jop.70150","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}