{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:17:18Z","timestamp":1788315438192,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is highly recurrent and metastatic; EP300 drives tumorigenesis, but its mechanism is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>EP300 expression was profiled in OSCC via databases, RT\u2010PCR, and Western blot. Knockdown effects on proliferation (CCK\u20108, colony), cell cycle, and apoptosis (flow cytometry) were measured. EP300\u2013Notch interplay was probed with Valproic acid, a Notch signaling activator (VPA) rescue assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our experimental results showed that\n                      <jats:styled-content style=\"fixed-case\">EP300<\/jats:styled-content>\n                      was upregulated in\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      Cell Lines. In addition, bioinformatics analysis showed that\n                      <jats:styled-content style=\"fixed-case\">EP300<\/jats:styled-content>\n                      upregulation was significantly associated with poor prognosis of\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      . Prior research and bioinformatics analyses have demonstrated a close relationship between\n                      <jats:styled-content style=\"fixed-case\">EP300<\/jats:styled-content>\n                      and the activation of the notch signaling pathway in\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      . After\n                      <jats:styled-content style=\"fixed-case\">EP300<\/jats:styled-content>\n                      knockdown in\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      cells treated with\n                      <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                      , our results indicated that\n                      <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                      could partially reverse the effects of\n                      <jats:styled-content style=\"fixed-case\">EP300<\/jats:styled-content>\n                      knockdown on cell proliferation, cell cycle, apoptosis, and\n                      <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                      processes in\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      Cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, we observed that EP300 knockdown suppressed the Notch signaling pathway, consequently inhibiting OSCC cell proliferation, the cell cycle, and EMT while also promoting apoptosis. These findings suggest that EP300 is crucial for OSCC cell growth and development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70159","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:26:19Z","timestamp":1781601979000},"page":"953-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibition of the\n                    <scp>EP300<\/scp>\n                    \/Notch Signaling Pathway Regulates Proliferation and Apoptosis in Oral Squamous Cell Carcinoma"],"prefix":"10.1111","volume":"55","author":[{"given":"Honglan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"Department of Stomatology North Sichuan Medical College  Nanchong China"},{"name":"Pingyang County Hospital of Traditional Chinese Medicine  Wenzhou 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