{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:07Z","timestamp":1791172447708,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fanconi anemia (FA) is a rare genetic disorder predisposing patients to oral squamous cell carcinoma (OSCC). Hematopoietic stem cell transplantation (HSCT) corrects bone marrow failure but may increase the risk of malignancies. Exfoliative cytology and the micronucleus (MN) test provide noninvasive assessment of genomic instability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare relative frequency of micronuclei (RFMN) in intact mucosa and OPMD lesions in FA patients, and to evaluate its correlation with time post\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010six FA patients were included: Group 1 (FA without HSCT,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), Group 2 (FA post\u2010HSCT without OPMD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913), and Group 3 (FA post\u2010HSCT with OPMD,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919). Exfoliative cytology samples were collected from buccal mucosa and OPMD lesions. MNs were manually counted to calculate RFMN. Nonparametric tests were applied to compare groups and the Wilcoxon signed\u2010rank test for intraindividual comparisons. Spearman's correlation and linear regression were used to evaluate associations with age and time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RFMN in OPMD lesions (Group 3) was significantly higher than in the integrous mucosa of the same patients (median 8 MN\/1000 cells, IQR 4\u201313; ~3.7\u2010fold increase;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). No significant differences were observed between Groups 1 and 2 in integrous mucosa. RFMN in integrous mucosa positively correlated with time post\u2010HSCT (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.694,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), independent of age and GVHD presence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FA patients, particularly post\u2010HSCT with OPMD, exhibited markedly increased genomic instability. RFMN increases over time, including time post\u2010HSCT, emphasizing the need for vigilant long\u2010term oral monitoring in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70166","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:18:26Z","timestamp":1783739906000},"page":"1045-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Micronucleus Frequency Test in Epithelial Cells Desquamated From the Oral Mucosa of Patients With Fanconi Anemia"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-3348","authenticated-orcid":false,"given":"B\u00e1rbara Soldatelli","family":"Ballardin","sequence":"first","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0073-013X","authenticated-orcid":false,"given":"P\u00e2mela Olivia","family":"de Moura","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5483-4582","authenticated-orcid":false,"given":"Pedro Leonardo Czmola","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-0782","authenticated-orcid":false,"given":"Juliana Lucena","family":"Schussel","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-7544","authenticated-orcid":false,"given":"Cassius Carvalho","family":"Torres\u2010Pereira","sequence":"additional","affiliation":[{"name":"Department of Stomatology Federal University of Paran\u00e1  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25726"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.02.013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106699"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32435"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5250790"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.03.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22249"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12169"},{"key":"e_1_2_10_10_1","first-page":"121","article-title":"Cancer of the Uterus: The Vaginal Smear in Its Diagnosis","volume":"59","author":"Traut H. 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