{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:04:07Z","timestamp":1789977847500,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoradionecrosis (ORN) is a serious complication of head and neck radiotherapy characterized by impaired bone healing. Infrared photobiomodulation therapy (IR\u2010PBMT) and dual\u2010wavelength photobiomodulation therapy (Dual\u2010PBMT) have been proposed as non\u2010invasive approaches to enhance bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010nine male Wistar\u2013Albino rats were included. An experimental protocol designed to induce mandibular ORN was performed using a single 35\u2009Gy radiation dose followed by mandibular molar extraction. Animals were allocated to four groups: control, radiotherapy plus extraction (RT\u2009+\u2009EX), RT\u2009+\u2009EX + IR\u2010PBMT, and RT\u2009+\u2009EX + Dual\u2010PBMT. IR\u2010PBMT was performed using a 940\u2009nm diode laser, whereas Dual\u2010PBMT combined 632\u2013650\u2009nm red and 904\u2013940\u2009nm infrared wavelengths. Both PBMT protocols were applied extraorally for 14 consecutive days. Bone samples were evaluated histopathologically and immunohistochemically for alkaline phosphatase (ALP), bone morphogenetic protein\u20102 (BMP\u20102), osteonectin (ONC), and tartrate\u2010resistant acid phosphatase (TRAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The RT\u2009+\u2009EX group exhibited severe inflammation and tissue destruction, whereas both PBMT\u2010treated groups showed reduced inflammation and partial epithelialization. Osteogenic marker expression was significantly lower and TRAP expression was significantly higher in the RT\u2009+\u2009EX group than in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Compared with the RT\u2009+\u2009EX group, both IR\u2010PBMT and Dual\u2010PBMT significantly increased ALP, BMP\u20102, and ONC expression and reduced TRAP expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). ALP expression was significantly higher in the Dual\u2010PBMT group than in the IR\u2010PBMT group, whereas no significant differences between the two protocols were observed for BMP\u20102, ONC, or TRAP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both IR\u2010PBMT and Dual\u2010PBMT improved the evaluated histological and bone\u2010remodeling parameters following radiotherapy and tooth extraction. Because the control animals did not undergo tooth extraction, comparisons with the control group should be interpreted cautiously. Although Dual\u2010PBMT produced a greater increase in ALP expression, the findings do not demonstrate the overall superiority of one PBMT protocol over the other. Both approaches may represent promising adjunctive strategies for mitigating radiation\u2010associated impairment of mandibular bone healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70186","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:16:55Z","timestamp":1789975015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Infrared and Dual\u2010Wavelength Photobiomodulation Therapy on Mandibular Bone Healing Following Radiotherapy and Tooth Extraction: An Experimental Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7784-9809","authenticated-orcid":false,"given":"G\u00f6ksal","family":"Keldal","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-9089","authenticated-orcid":false,"given":"Sefa","family":"\u00c7olak","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-6748","authenticated-orcid":false,"given":"Asiye","family":"Yanc\u0131","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-2984","authenticated-orcid":false,"given":"G\u00fclhan G\u00fcler","family":"Avc\u0131","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9015-3579","authenticated-orcid":false,"given":"Rutkay F\u0131rat","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-075X","authenticated-orcid":false,"given":"Bilal","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-8564","authenticated-orcid":false,"given":"Yunus","family":"Balel","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Oral and Maxillofacial Surgery Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-2542","authenticated-orcid":false,"given":"Fikret","family":"Gevrek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Tokat Gaziosmanpa\u015fa University  Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(83)90294\u2010x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.10.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20121"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0332"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.02.017"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.08.021"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.09.009"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20101097.2008.00394.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3934\/biophy.2017.3.337"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454704774076208"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20920"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.03.016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.10.011"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.02.008"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.11.008"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.93224"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims\u201024\u201047"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010024\u201001907\u20103"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.4038"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000459"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.2.028002"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104381"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010022\u201002678\u20101"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22787"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508\u2010008\u20100932\u20106"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00011357"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010024\u201003973\u20109"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.76147"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13226890"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104054"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.31900\/ijl.v22i2.398"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.70186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:16:56Z","timestamp":1789975016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":31,"alternative-id":["10.1111\/jop.70186"],"URL":"https:\/\/doi.org\/10.1111\/jop.70186","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jop.70186"}}