{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:46:50Z","timestamp":1791856010812,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573289, 82605122"],"award-info":[{"award-number":["82573289, 82605122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["ZDX22001"],"award-info":[{"award-number":["ZDX22001"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Although Glycerol\u20103\u2010phosphate acyltransferase 3 (GPAT3)\u2010mediated lipid metabolic reprogramming has been recognized as a driver of tumor progression, its prognostic significance and underlying mechanisms in oral squamous cell carcinoma (OSCC) remain to be fully elucidated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study included 77 primary OSCC samples, expression pattern of GPAT3 and the prognostic value were analyzed by immunohistochemistry. In\u00a0vitro functional experiments included cell viability and cell migration. Gene and protein expressions was analyzed via immunofluorescence staining, flow cytometry, RT\u2010PCR, and western blotting. Lipids profiles were determined by mass spectrometry.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n GPAT3 was broadly expressed in tumor cells, fibroblast\u2010like cells, and tumor\u2010infiltrating lymphocytes, with significantly higher expression at the invasive tumor front than in the tumor center. Elevated GPAT3 expression was positively correlated with adverse clinical outcomes and poor prognosis. In\u00a0vitro experiments showed that both GPAT3 knockdown and overexpression markedly altered OSCC cell proliferation and migration. GPAT3 inhibition reduced the levels of several phospholipids, including Cer, PS, PE, and PC, accompanied by decreased expression of the invasion\u2010related proteins p\u2010FAK and p\u2010Myosin II.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n GPAT3 regulates the invasive behavior of OSCC by mediating lipid metabolic reprogramming, serving as a biomarker for the clinical prognosis of OSCC patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.70188","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:00:48Z","timestamp":1791853248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GPAT3<\/scp>\n Promotes Oral Squamous Cell Carcinoma Invasion by Reprogramming Lipid Metabolism"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2855-8345","authenticated-orcid":false,"given":"Zixian","family":"Li","sequence":"first","affiliation":[{"name":"Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"},{"name":"Department of Oral Pathology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9265-5148","authenticated-orcid":false,"given":"Zhiheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"},{"name":"Department of Oral Pathology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiren","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"},{"name":"Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuya","family":"Yu","sequence":"additional","affiliation":[{"name":"Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-990X","authenticated-orcid":false,"given":"Huiling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3890-3884","authenticated-orcid":false,"given":"Yanhong","family":"Ni","sequence":"additional","affiliation":[{"name":"Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-2413","authenticated-orcid":false,"given":"Zhiyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-023-00418-5","article-title":"Author Correction: Head and Neck Squamous Cell Carcinoma","volume":"9","author":"Johnson D. 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