{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:54:23Z","timestamp":1791417263930,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305781\/2024\u20103"],"award-info":[{"award-number":["305781\/2024\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with limited prognostic biomarkers, in which metabolic reprogramming contributes to tumor progression. Amino acid transporters of the solute carrier family have emerged as key regulators of cancer biology; however, the role of solute carrier family 7 member 3 (SLC7A3), a cationic amino acid transporter involved in arginine uptake, remains poorly characterized in OSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SLC7A3 expression was evaluated using RNA expression data from the Cancer Genome Atlas OSCC cohort (TCGA\u2013OSCC), and protein levels were assessed by immunohistochemistry in a tissue microarray comprising 67 OSCC samples matched with normal oral tissue and 18 metastatic lymph nodes. Associations with clinicopathological features and survival were analyzed using chi\u2010squared tests, Kaplan\u2013Meier curves, and Cox regression. Functional assays, including cell cycle, apoptosis, migration, and invasion analyses, were performed in HSC3 cells following SLC7A3 knockdown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In TCGA\u2010OSCC, SLC7A3 mRNA levels were significantly lower in tumors than in nontumor tissues (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), with no association with disease\u2010specific or disease\u2010free survival. At the protein level, SLC7A3 was significantly upregulated in tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), and high expression was associated with early clinical stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and improved disease\u2010specific survival, remaining significant in multivariate Cox analysis (HR: 0.18, 95% CI: 0.07\u20130.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Functionally, SLC7A3 knockdown did not alter cell cycle distribution or apoptosis but significantly increased OSCC cell migration and invasion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High SLC7A3 protein levels were associated with OSCC cell migration and invasion and improved disease\u2010specific survival, suggesting its potential as an indicator of tumor aggressiveness and a promising prognostic potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.70190","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:45:27Z","timestamp":1791416727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SLC7A3<\/scp>\n                    Expression Is Associated With Migration, Invasion, and Survival in Oral Squamous Cell Carcinoma"],"prefix":"10.1111","author":[{"given":"Lilianny Querino Rocha","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Graduate Program in Oral Biology, School of Dentistry University of Campinas  Piracicaba Brazil"},{"name":"Lady Davis Institute for Medical Research, Sir Mortimer B. Davis\u2010Jewish General Hospital, McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-7672","authenticated-orcid":false,"given":"Everton Freitas","family":"de Morais","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba Brazil"},{"name":"Laboratory of Biotechnology and Physiology of Reproduction Federal University of Ceara  Sobral Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6651-1678","authenticated-orcid":false,"given":"Cintia Eliza","family":"Marques","sequence":"additional","affiliation":[{"name":"Graduate Program in Oral Biology, School of Dentistry University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-8997","authenticated-orcid":false,"given":"Bruno Cesar","family":"da Costa","sequence":"additional","affiliation":[{"name":"Graduate Program in Oral Biology, School of Dentistry University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Haach","family":"T\u00e9o","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Translational Immunology Program (TRIMM) University of Helsinki  Helsinki Finland"},{"name":"iCAN Digital Precision Cancer Medicine Flagship University of Helsinki  Helsinki Finland"},{"name":"Research Unit of Population Health, Department of Oral Pathology University of Oulu and Oulu University Hospital  Oulu Finland"},{"name":"Medical Research Center Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-3046","authenticated-orcid":false,"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Graduate Program in Oral Biology, School of Dentistry University of Campinas  Piracicaba Brazil"},{"name":"Department of Oral Diagnosis, School of Dentistry University of Campinas  Piracicaba Brazil"},{"name":"Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Daniela Silva","family":"Wurzba","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Sir Mortimer B. Davis\u2010Jewish General Hospital, McGill University  Montreal Canada"},{"name":"Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis\u2010Jewish General Hospital McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2020.00003"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000224\u20103"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010023\u201000249\u2010w"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13406"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw5473"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202201404"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plrev.2025.10.001"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115748928279007231130070056"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698\u2010025\u201001198\u20109"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232\u2010006\u20100875\u20107"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010026\u201001697\u20100"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216412"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.037"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010018\u20101535\u2010y"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201034723\u20108"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr\u201020\u20102744"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs\u201021\u2010909"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4277"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.70032"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010015\u20101944\u2010z"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010020\u20100258\u20104"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.014"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.70190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.70190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:45:28Z","timestamp":1791416728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.70190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":22,"alternative-id":["10.1111\/jop.70190"],"URL":"https:\/\/doi.org\/10.1111\/jop.70190","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jop.70190"}}