{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:24:33Z","timestamp":1773005073173,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T00:00:00Z","timestamp":1492560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["25463276"],"award-info":[{"award-number":["25463276"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Prosthodontics"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the efficacy of twin\u2010block (i.e., allows mouth opening) and fixed (i.e., maintains mouth closure) mandibular advancement splints (MASs) for the treatment of obstructive sleep apnea\u2013hypopnea syndrome (OSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>From 2011 to 2013, 23 patients with OSA in the twin\u2010block group, and from 2013 to 2015, 29 patients in the fixed MAS group were included. All patients underwent polysomnography before and after 3 months of treatment. The two sets of polysomnographic and cephalometric variables were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant difference (<jats:italic>p<\/jats:italic> &lt; 0.001) was observed in the apnea\u2013hypopnea index before and after MAS treatment in both groups (twin\u2010block group: 20.6 \u00b1 11.5 vs. 14.7 \u00b1 9.4; fixed group: 21.4 \u00b1 15.2 vs. 11.2 \u00b1 9.7). In the twin\u2010block group, 5 patients (21.7%) were complete responders, 9 (39.1%) were fair responders, and 9 (39.1%) were nonresponders; the corresponding figures for the fixed group were 14 (48.3%), 9 (31.0%), and 6 (20.7%) patients. A significant between\u2010group difference was observed in the distribution of responders (<jats:italic>p<\/jats:italic> = 0.046). The fixed group showed a significant improvement in the snoring index (<jats:italic>p<\/jats:italic> = 0.003), arousal index (<jats:italic>p<\/jats:italic> = 0.036), and desaturation rate (<jats:italic>p<\/jats:italic> = 0.012). Finally, the change in incisal overjet was larger in the fixed group than in the twin\u2010block group (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that fixed oral appliances are superior in treating OSA, based on their ability to prevent mouth opening and reduce incisal overjet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jopr.12619","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T13:45:27Z","timestamp":1492609527000},"source":"Crossref","is-referenced-by-count":18,"title":["Therapeutic Efficacy of Twin\u2010Block and Fixed Oral Appliances in Patients with Obstructive Sleep Apnea Syndrome"],"prefix":"10.1111","volume":"28","author":[{"given":"George","family":"Umemoto","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Center for Sleep Disorders at Fukuoka Fukuoka Urasoe Clinic  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Center for Sleep Disorders at Fukuoka Fukuoka Urasoe Clinic  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Medicine Fukuoka University  Fukuoka 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