{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:39:04Z","timestamp":1792737544118,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Prosthodontics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate marginal bone loss (MBL) of dental implants inserted in active lichen planus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study included 59 subjects divided into 3 groups depending on their lichen planus diagnosis and administration of a low dose of corticosteroids: 17 healthy individuals, 20 controlled lichen planus patients controlled using low doses of systemic corticosteroids, and 22 noncontrolled lichen planus patients. During 4\u2010year follow\u2010up sessions MBL was evaluated, and biopsies were collected from lichen planus patients and examined. Two\u2010way ANOVA was used to analyze the data (\u03b1 = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference in MBL between healthy and controlled patients; however, noncontrolled patients exhibited increased MBL (F = 1309, <jats:italic>p<\/jats:italic> &lt; 0.001) which reached 2.53 mm after 4 years. There were significant interactions between state of the disease (F = 1309, <jats:italic>p<\/jats:italic> &lt; 0.001), evaluation time (F = 317, <jats:italic>p<\/jats:italic> &lt; 0.001), and interaction between state of the disease and observation time (F = 159, <jats:italic>p<\/jats:italic> &lt; 0.001). Histopathologic examination of collected biopsies revealed healthy tissue architecture of the controlled patients, while inflammatory cellular infiltration and signs of classical destructive tissue were observed for noncontrolled patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lichen planus patients receiving dental implants should be controlled on a low\u2010dose of corticosteroids to prevent accelerated MBL and to reduce remission of clinical manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jopr.12993","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T10:37:07Z","timestamp":1540463827000},"page":"519-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus. Part II 4\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-9932","authenticated-orcid":false,"given":"Aya Khamis","family":"Khamis","sequence":"first","affiliation":[{"name":"Oral Pathology Department, Faculty of Dentistry Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa Nabil","family":"Aboushelib","sequence":"additional","affiliation":[{"name":"Dental Biomaterials Department, Faculty of Dentistry Alexandria University  Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Hamdy","family":"Helal","sequence":"additional","affiliation":[{"name":"Oral Medicine, Diagnosis, Radiology, and Periodontology Department, Faculty of Dentistry Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"546","article-title":"Time\u2010resolved fluorescence spectroscopy for the diagnosis of oral lichen planus","volume":"2018","author":"Gorpas D","journal-title":"Clin Exp Dermatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2018.02.003"},{"key":"e_1_2_7_4_1","first-page":"1161","article-title":"Oral lichen planus: an overview of potential risk factors, biomarkers and treatments","volume":"19","author":"Nosratzehi T","year":"2018","journal-title":"Asian Pacific J Cancer Prev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12712"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12821"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.01.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20181870"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.219"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00894.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2519-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12918"},{"key":"e_1_2_7_13_1","first-page":"61","article-title":"Clindamycin\u2010induced maculopapular exanthema with preferential involvement of Striae Distensae: a Koebner phenomenon?","volume":"26","author":"Monteagudo B","year":"2018","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_7_14_1","first-page":"401","article-title":"Evaluation of the effects of dental implants on oral lesions","volume":"16","author":"Agha\u2010Hosseini F","year":"2015","journal-title":"J Contemp Dent Pr"},{"key":"e_1_2_7_15_1","first-page":"599","article-title":"Dental implants in patients with oral lichen planus: a narrative review","volume":"45","author":"Pons\u2010Fuster A","year":"2014","journal-title":"Quintessence Int"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0695-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"ScullyC CarrozzoM:Oral mucosal disease: lichen planus.2008;46:15\u201021","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpme.2017.12.069"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2014.10.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopr.12379"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12373"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2012.12.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7305"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00347.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02192.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2014.914570"},{"key":"e_1_2_7_30_1","first-page":"53","article-title":"Diagnosis and treatment of lichen planus","volume":"84","author":"Usatine RP","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-014-2791-6"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01537.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-013-1288-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17056"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00455.x"}],"container-title":["Journal of Prosthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjopr.12993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jopr.12993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jopr.12993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jopr.12993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T19:36:08Z","timestamp":1694374568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jopr.12993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,14]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/jopr.12993"],"URL":"https:\/\/doi.org\/10.1111\/jopr.12993","archive":["Portico"],"relation":{},"ISSN":["1059-941X","1532-849X"],"issn-type":[{"value":"1059-941X","type":"print"},{"value":"1532-849X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,14]]},"assertion":[{"value":"2018-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}