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Due to the rarity of this oral form of systemic disease, little has been elucidated on management of the resulting impaired oral function. While surgery can address the size of the tongue, it carries significant morbidities, enlargement can recur, and does not address adverse tooth positioning. Prosthetic rehabilitation can more aptly restore oral function but it also needs to be tailored based on the patient's expectations and goals as well as biologic and mechanical parameters of treatment. This report discusses an effective and noninvasive application of a tooth\u2010supported, removable prosthesis with an onlay occlusal design to restore occlusion, speech, and esthetics in a patient with tongue\u2010based amyloidosis.<\/jats:p>","DOI":"10.1111\/jopr.13236","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T04:56:43Z","timestamp":1597467403000},"page":"725-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prosthetic Rehabilitation with Amyloidosis of the Tongue"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-8272","authenticated-orcid":false,"given":"Sarah Kay Youny","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dental Specialties Mayo Clinic  200 First Street SW Rochester MN 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