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An edentulous patient with hemiglossectomy and heavily resorbed mandible consulted for complete denture rehabilitation to improve their masticatory function and speech. Master casts, wax rims, and piezographic impression were scanned for digital prosthetic work. Two digital try\u2010ins were performed to respect the neutral zone: try\u2010in 1 with posterior crossbite and try\u2010in 2 without crossbite. Muscle activity and mandibular kinetics were performed for each try\u2010in following the MAC2 protocol (six criteria): muscular tone, contraction synchrony, contraction efficiency, interocclusal rest distance, amplitude of mandibular movement, and velocity. Try\u2010in 2 showed better data than try\u2010in 1 in all criteria: muscle tone (respectively 71% vs. 59%), contraction synchrony (79% vs. 75%), contraction efficiency (85% vs. 77%), an increase in range of motion of 3.3\u00a0mm, and a better velocity (0.35\u00a0\u00b1\u00a00.12\u00a0s vs. 0.57\u00a0\u00b1\u00a00.14\u00a0s, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). The piezographic impression, in combination with CAD\u2013CAM, allowed the comparison of two prosthetic designs and the selection of the try\u2010in with the best neuro\u2010musculo\u2013kinetic results.<\/jats:p>","DOI":"10.1111\/jopr.13685","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T13:49:30Z","timestamp":1679838570000},"page":"461-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Digital optimization of teeth setup in an edentulous patient with partial glossectomy: A case report"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-7392","authenticated-orcid":false,"given":"Mathieu","family":"Carri\u00e8re","sequence":"first","affiliation":[{"name":"Faculty of Dental Medicine, Bordeaux University, Bordeaux University Hospital Saint\u2010Andr\u00e9 Hospital  Bordeaux 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