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The review outlines the etiopathogenesis, clinical features, and management strategies of denture stomatitis from an interdisciplinary perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>English\u2010language articles relating to the definition, incidence, gender distribution, geographical distribution, etiology, pathogenesis, symptoms, signs, treatment, and prognosis of denture stomatitis were retrieved via electronic literature search. Relevant articles were summarized for this manuscript with a view toward providing pragmatic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Denture stomatitis represents a very common, multifactorial infectious, inflammatory, and hyperplastic condition which is primarily caused by poor oral hygiene, poor denture hygiene, and full\u2010time; mainly night\u2010time denture wear, bringing about the emergence of advanced<jats:italic>Candida\u2010<\/jats:italic>containing polymicrobial biofilms in close proximity to the host's mucosal tissues. Denture stomatitis shares clinically relevant associations with dental caries, periodontitis, median rhomboid glossitis, angular cheilitis, aspirational pneumonia, and associated mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Effective, long\u2010term treatment of denture stomatitis relies upon sustained patient\u2010driven behavioral change which should focus on daily prosthesis\u2010level cleaning and disinfection, removal of dentures at night, every night, engagement with professional denture maintenance, and when required, denture replacement. Antifungal medications offer limited benefits outside of short\u2010term use due to the emergence of antifungal resistance. For frail, older, medically compromised, and nursing home populations, treatment of denture stomatitis lowers the risk of aspirational pneumonia and associated mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jopr.13687","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T13:27:55Z","timestamp":1680096475000},"page":"560-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Denture stomatitis\u2014An interdisciplinary clinical review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-1788","authenticated-orcid":false,"given":"David E.","family":"McReynolds","sequence":"first","affiliation":[{"name":"Dublin Dental University Hospital Trinity College Dublin Dublin 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