{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:50:08Z","timestamp":1776491408138,"version":"3.51.2"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Prosthodontics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Older adults with removable dentures experience high rates of both caries (when the natural dentition remains) and salivary gland dysfunction. While many commercial dental therapeutic agents target these two interrelated problems, none have been labeled for use on the fitting surface of removable dentures. Off\u2010label use of MI Paste (GC America, Alsip, IL), a dental therapeutic containing casein\u2010phosphopeptide\u2010amorphous\u2010calcium\u2010phosphate (CPP\u2010ACP), was investigated following its application to the fitting surface of complete denture(s) with subsequent effects on salivary conditions measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Salivary flow rate and pH were recorded at baseline and 15\u00a0min following the application of 1\u00a0mL of CPP\u2010ACP paste to the fitting surface of each participant's denture through whole saliva collection. To assess buffering capacity, equivalent volumes of 0.01\u00a0M lactic acid were added to the collected saliva samples, and pH reduction was measured. Comparisons of salivary parameters between baseline and post\u2010CPP\u2010ACP paste application and between subjects with and without self\u2010reported xerostomia were conducted using a paired\u2010sample t\u2010test, Wilcoxon signed\u2010rank test, or two\u2010sample <jats:italic>t<\/jats:italic>\u2010test as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 28 participants (mean age\u00a0=\u00a070.3\u00a0\u00b1\u00a013.7\u00a0years, 17 males), 11 reported xerostomia. CPP\u2010ACP\u2010paste application was associated with decreased pH reduction during acid challenge compared to baseline (0.95\u00a0\u00b1\u00a00.24 vs. 1.54\u00a0\u00b1\u00a00.53, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and a higher final pH following acid challenge (5.93\u00a0\u00b1\u00a00.34 vs. 5.40\u00a0\u00b1\u00a00.66, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). While the flow rates observed at post\u2010CPP\u2010ACP paste application were greater than those at baseline, the difference was not statistically significant (0.67\u00a0\u00b1\u00a00.44\u00a0mL\/min vs. 0.55\u00a0\u00b1\u00a00.34\u00a0mL\/min, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.053). No significant differences were found in any salivary parameters between participants with or without self\u2010reports of xerostomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings highlight potential positive effects on salivary conditions following the application of the CPP\u2010ACP\u2010containing product, MI Paste, to the fitting surface of a removable complete denture as a potential caries\u2010risk\u2010management tool when natural dentition remains. Determining the caries\u2010preventive clinical significance will require longer\u2010term trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jopr.13797","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:03:01Z","timestamp":1700071381000},"page":"427-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CPP\u2010ACP paste's effect on salivary conditions in patients with removable dentures"],"prefix":"10.1111","volume":"33","author":[{"given":"Colton","family":"Curtis","sequence":"first","affiliation":[{"name":"University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Computational Biology University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-5466","authenticated-orcid":false,"given":"Robert D.","family":"Bowers","sequence":"additional","affiliation":[{"name":"Department of Family Dentistry University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520908533"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517750572"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12511"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201802302"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228523"},{"key":"e_1_2_8_7_1","volume-title":"Prevalence of tooth loss among older adults: United States","author":"Fleming E"},{"key":"e_1_2_8_8_1","unstructured":"Centers for Disease Control.Oral Health Surveillance Report: Trends in Dental Caries and Sealants Tooth Retention and Edentulism United States 1999\u20132004 to 2011\u20132016.https:\/\/www.cdc.gov\/oralhealth\/publications\/OHSR\u20102019\u2010index.html#print"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2007.01435.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.04.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274\u2010012\u20101030\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2013.1095"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2015.01.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2017.660"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750101101"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760091101"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368\u2010019\u201000490\u20100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a43637"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196660"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350903160563"},{"issue":"5","key":"e_1_2_8_21_1","article-title":"Minimal intervention dentistry: part 1. 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